News and Events

News & Events

Find out more about the latest news and forthcoming events of the Newcastle Fibrosis Group and subscribe to our newsletter

A new NFRG review by Teresa Borrello and Derek Mann published in the British Journal of Pharmacology

Chronic liver diseases: From development to novel pharmacological therapies

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(pub: 09/05/2022)

A team effort and collaborative work led by Jack Leslie results in a new publication in Gut

CXCR2 inhibition enables NASH- HCC immunotherapy

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(pub: 04/05/2022)

A new review by NFRG by Jack Leslie, Daniel Geh and Derek Mann in Journal of Hepatology

Metabolic dysfunction and cancer in HCV: shared pathways and mutual interactions

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(pub: 16/02/2022)

A new NFRG review by Fiona Oakley published in Nature Reviews Gastroenterology & Hepatology

Interrogating mechanisms of liver fibrosis with omics

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(pub: 21/01/2022)



A new NFRG review by Daniel Geh, Jack Leslie and Derek Mann published in Nature Reviews Gastroenterology & Hepatology

Neutrophils as potential therapeutic targets in hepatocellular carcinoma

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(pub: 12/01/2022)


A new book chapter in the Encyclopaedia of Respiratory Medicine By Will Reilly, Rachel Burgoyne and Lee Borthwick

The Role of Epithelial Damage in the Pulmonary Immune Response

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(pub: 01/12/2021)


A new Review by Rachel Burgoyne and Lee Borthwick in MDPI

The Role of Epithelial Damage in the Pulmonary Immune Response

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(pub: 25/11/2021)


New NFRG publication lead by Maria Garcia published in Hepatology

An mTORC1-Plin3 pathway is essential to activate lipophagy and protects against hepatosteatosis

Read the abstract

(pub: 13/07/2021)


Letizia Marchetti Best Flash Talk at BIRA Inaugural Conference

Possible systemic roles of hepatic NFkB1 in inflammageing

Read the abstract

(pub: 05/07/2021)


New NFRG / Mayo Clinic publication in The EMBO Journal

Neutrophils induce paracrine telomere dysfunction and senescence in ROS‚Äźdependent manner

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(pub: 15/03/2021)


Prof. Derek Mann's new discovery

Through multiple experiments, Prof. Derek Mann, a major figure of the NFRG team, has reached a notable conclusion

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(pub: 16/02/2021)


Congratulations for a new NFRG article

On January 14th, Newcastle Fibrosis Research Group had another brilliant article published in Scientific Reports, thanks to the collective work of Dr. Jack Leslie, Professor Fiona Oakley and Dr. Saimir Luli.

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(pub: 15/01/2021)


NFRG team effort for a new published article

Along with other scientists, the NFRG members have worked hard on a new paper published in the Journal of Immunology.

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(pub: 14/01/2021)


Prof. Jelena Mann, co-author in Gastroenterology

Prof. Jelena Mann, a Principal Investigator within NFRG, has recently brought her contribution to an article, freshly published in Gastroenterology.

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(pub: 16/12/2020)

Very good news for Laura Sabater and NFRG

NFRG congratulates PhD student Laura Sabater and Prof Jelena Mann, for having a new article published in the renowned Scientific Reports journal.

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(pub: 14/12/2020)

Prof. Jelena Mann is a guest speaker at the NASH Summit

NFRG's Principal Investigator, Prof. Jelena Mann will be a guest speaker at this prestigious event, on the 15th of December.

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(pub: 07/12/2020)

Dr. Lee Bortwick gives talk at the 4th AFDD Summit

On Tuesday, the 17th of November 2020, Dr. Lee Borthwick, was an expert speaker at the 4th Annual Digital Antifibrotic Drug Developement Summit.

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(pub: 02/12/2020)

Hannah Paish's presentation gets rewarded

Hannah Paish, a valuable member of the Newcastle Fibrosis Research Group received the Joint 2nd Place Presentation Prize, for her impressive talk.

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(pub: 30/11/2020)

Dr. Jack Leslie's new captivating article

Dr. Jack Leslie, an important member of the Newcastle Fibrosis Research Group, has a new paper published in the famous journal Nature Metabolism.

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(pub: 09/11/2020)

A valuable prize for Newcastle University, NFRG and Dr. Marco Zaki

Professors Fiona Oakley and Helen Reeves, from Newcastle University, along with Dr. Marco Zaki, from Minia University, Egypt, a former NFRG PhD student, are among the winners of Newton Prize 2020

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(pub: 09/11/2020)

Important discovery for Dr. Nick Kalson

NFRG celebrates Dr. Nick Kalson's article, published in the prestigious The Bone and Joint Journal

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(pub: 14/10/2020)

Dr. Marco Zaki shortlisted for the Newton Prize 2020

Former NFRG Ph.D. student shortlisted for a project with Prof. Fiona Oakley and Prof. Helen Reeves

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(pub: 13/10/2020)

Great achievement for Dr. JacK Leslie and NFRG

NFRG has a major new scientific study accepted for publication in Nature Metabolism

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(pub: 01/10/2020)

Duchenne UK announces a grant of £53,000 supporting NFRG

Aim: speed up the diagnosis of cardiac fibrosis in female carriers of Duchenne Muscular Dystrophy

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(pub: 28/09/2020)

NFRG Work led By Lee Borthwick published in JCI Insight

FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis

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(pub: 28/02/2020)

Duchenne UK funds a new £163,637 grant to NFRG

Objective: helping to improve the success rate of clinical trials to fight Duchenne Muscular Dystrophy

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(pub: 30/01/2020)

Lee Borthwick contributes to publication in PNAS with the Universities of Manchester, Oxford, UCL, and Toronto

The circadian clock protein REVERBα inhibits pulmonary fibrosis development

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(pub: 06/01/2020)

Jelena Mann awarded the Roy Cameron Medal

She gave the 2019 Roy Cameron Lecture "Epigenetics and Liver Fibrosis" on the 20th of November at the Royal College of Pathologists

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(pub: 22/11/2019)

A new NFRG review focusing on PCLS published in Current Opinion in Pharmacology

Implementation of pre-clinical methodologies to study fibrosis and test anti-fibrotic therapy

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(pub: 12/11/2019)

NFRG Collective work leads to a new paper in Gastroenterology in November 2019

Fibrogenic Activity of MECP2 Is Regulated by Phosphorylation in Hepatic Stellate Cells

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(pub: 04/11/2019)

Meet Jelena Mann and Lee Borthwick at NASH Summit 2019 in London

NFRG Principal Investigators will present the Precision-Cut Liver Slices technology at NASH Summit Europe, 23-25th October 2019

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(pub: 21/10/2019)

Jack Leslie Awarded Best Talk Price at FMS Post-Doc Symposium for his talk:

Combined CXCR2 inhibition and Anti-PD1 therapy alters immune cell infiltration and limits HCC progression

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(pub: 02/07/2019)

Hannah Paish has a new paper published in the Journal of Orthopaedic Research

Chronic, active inflammation in patients with failed total knee replacements undergoing revision surgery

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(pub: 01/07/2019)

Prof Jelena Mann Guest Speaker at Annual NASH Summit in Boston

Giving talks, leading workshop, charing session and presenting a poster: NFRG represented by a major participant at a world-class event.

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(pub: 07/05/2019)

Lucy Gee: poster and talk at EASL International Liver Congress 2019

"Obeticholic acid limits cholestasis induced cognitive decline by maintaining blood-brain barrier integrity and preserving neuronal health"

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(pub: 18/04/2019)

Dr Caroline Wilson talks at 33rd Genes and Cancer Annual Meeting in Cambridge

Title: "Exercise improves age-related inflammation, liver disease and cancer"

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(pub: 15/04/2019)

Tim Hardy's VIVA Seminar will be held on Monday 25th February

Title: "The Role of Methylation in Hepatic Fibrosis Progression in Non-Alcoholic Fatty Liver Disease"

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(pub: 07/02/2019)

Jelena Mann guest speaker at Keystone Symposia on Integrated Pathways of Disease in NASH and NAFLD

Talk: "Epigenetics of Fibrosis and Cancer in Liver Disease"

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(pub: 28/01/2019)

Derek Mann gives the opening talk at NU TechNet 2019 event.

"Team-Science - How technicians got me to the top of my academic profession"

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Lauren Davison: highly commended award at the British Thoracic Society Winter Meeting

Lauren has been awarded the 2018 BTS/BALR/BLF Early Career Investigator Finalist Prize

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(pub: 11/12/2018)

Hannah Paish is forging a new career path for technicians

Hannah is combining her PhD studies with working as a research technician

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(pub: 25/10/2018)

Caroline Wilson invited speaker at European NF-κB subunit meeting

Progression of NFKB1 regulated inflammatory liver disease and cancer are suppressed by structured exercise

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(pub: 10/10/2018)

Student stories: Lee Borthwick, an inspiring research supervisor

Discover the video testimonial of one of our undergrad students: Ananya Baksi

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(pub: 03/10/2018)

New NFRG psoter presented by Hannah Paish at IST Technical Conference 2018

A novel bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slices

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(pub: 24/09/2018)

New NFRG paper by Julia Concetti published in Cells



NFKB1 and Cancer: Friend or Foe?

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(pub: 17/09/2018)

NFRG paper led by Tyrell Cartwright published in BBA Gene Regulatory Mechanisms

HDAC1 interacts with the p50 NF-κB subunit via its nuclear localization sequence to constrain inflammatory gene expression

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(pub: 14/09/2018)

Duchenne UK and NFRG announce a new collaboration

Projects aims to develop human cardiac precision cut slices as a novel platform for target identification and validation in Duchenne Muscular dystrophy.

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(pub: 13/09/2018)

14-15/09/2018 - Jelena Mann invited as Guest Speaker at AASLD Hepatic Fibrosis Single Topic conference

Talk title: Epigenetic Regulation of Stellate Cell Activation

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(pub: 11/09/2018)

13-18/08/2018 - Jelena Mann and Lee Borthwick as guest speakers in Aegean Conference In Greece at

2nd International Conference on Tissue Repair, Regeneration, and Fibrosis

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(pub: 31/05/2018)

Emma Gilmour awarded the British Society for Immunology Undergraduate Prize

"The effect of chronic ibuprofen treatment on lung inflammation as measured by B lymphocyte infiltration"

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(pub: 31/05/2018)

Dr Lee Borthwick co-autohor of paper published in International Journal of Molecular Sciences

"Targeting the Bacterial Cytoskeleton of the Burkholderia cepacia Complex for Antimicrobial Development: A Cautionary Tale"

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(pub: 31/05/2018)

Prof Jelena Mann invited as Guest Speaker at EASL International Liver Congress 2018

"Liquid Biopsy for Liver Fibrosis" with Prof Mudjat Zeybel "Plasma cell-free DNA methylation: a liquid biomarker of hepatic fibrosis"

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(pub: 26/03/2018)

Dr. Worrell talks at British Society for Investigative Dermatology Annual Meeting, Feb 26th-28th, London.

Title: THE NF-kB Subunit c-Rel is a Core Regulator of Matrix Production and Dermal Fibrosis

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(pub: 26/03/2018)

Epigenetic Matters: A Public Lecture by Prof Jelena Mann

On April 11th at 14:00 - Title: Your DNA is not your destiny - How epigenetics and environment shapes your life - Event open to all members of the public

Read More and download flyer 

(pub: 05/03/2018)

Derek Mann Gives talk at 38th European Workshop for Rheumatology Research

Fibrogenic-Inflammatory Cross-Talk in Post-Total Knee Arthroplasty - A Human Model of Induced Chronic Fibrosis

Download presentation 

(pub: 26/02/2018)

Michelle James, NFRG Ph.D. Student will Chair next ICM Research Seminar

Wednesday, February 21st - Dental Lecture Theatre F, Medical School 1:00pm - 2:00pm

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(pub: 19/02/2018)

Nuformix announces a positive outcome of a pilot study on multiple fibrotic diseases.

With Fibrofind, Nuformix has completed pilot pre-clinical studies that further validate the potential for its NXP002 programme in treating fibrosis.

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(pub: 13/02/2018)

Dr. Worrell will give talk at 5th Systemic Sclerosis World Congress Feb 15th-17th in Bordeaux.

Title: Myeloid specific Deletion of C-REL protects against fibrosis in the bleomycin mouse model of systemic sclerosis

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(pub: 09/02/2018)

NFRG paper published in GUT

A cooperation between NFRG, University of the Basque Country and Medical University of Vienna leads to new paper entitled: Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage

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(pub: 01/02/2018)

CEPA Biobank Newcastle officially launched

On January 19th, the CEPA biobank which will benefit the healthcare of patients, researchers and companies, has been launched in Royal Victoria Infirmary

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(pub: 23/01/2018)

NFRG paper published in GUT

A cooperation between NFRG, University of Erlangen-Nuremberg and Istanbul Bilim University results in a new publication entitled: Plasma cell-free DNA methylation: a liquid biomarker of hepatic fibrosis

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(pub: 23/01/2018)

ACMEDSCI Talk by Derek Mann

On 11th of January, Prof Derek Mann FMedSci, gave a motivating talk in the frame of the Academy of Medical Sciences Regional Celebration in Newcastle

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(pub: 15/01/2018)

New NFRG paper in Journal of Pathology

Fibroblasts Promote Inflammation and Pain via Interleukin-1α–Induction of the Monocyte Chemoattractant CCL2

Read article

(pub: 19/12/2017)

NFRG mobilised for Movember

The Fibrostahe team has gathered more than £230 for Men's health projects focusing on prostate cancer, testicular cancer, and mental health and suicide prevention.

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(pub: 01/12/2017)

Dr Marina Garcia gives talk ICM Research Seminar

Dr. Marina Garcia gave a remarkable talk entiled: "Autophagic approaches to prevent fatty liver disease"

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(pub: 23/11/2017)

VIVA Seminar: Congratulations Dr. Saimir Luli

NFRG PhD Student, Saimir Luli, gave his VIVA Seminar on November 16th. All the team is very proud of calling now him "Doctor Luli"

Read abstract

(pub: 17/11/2017)

New NFRG review in Advanced Drug Delivery Reviews

Epigenetic reprogramming in liver fibrosis and cancer written by Dr Caroline Wilson, Dr Lee Borthwick and Prof Derek Mann

Read abstract and access full review

(pub: 16/11/2017)

Dr Caroline Wilson gave presentation in ICM PI Seminar Series on November 13th

Presentation entitled "Chronic inflammation and its role in liver disease and cancer"

Read abstract

(pub: 14/11/2017)

Olivier Govaere in AASLD Liver Meeting 2017

Dr. Olivier Govaere presented his poster entitled "Lipopolysaccharide increases the release of CXCL5 in an ex-vivo model for human non-alcoholic fatty liver disease"

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(pub: 07/11/2017)

Laura Sabater scores at NEPG Conference 2017

With a talk entitled"Protective heritable reprogramming of hepatic wound healing in liver fibrosis" Laura Sabater represents NFRG at NEPG Conference 2017

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(pub: 31/10/2017)

Lab talk given by Promega representative (pub. 30/10/2017)

Promega product specialist Leanne Wickens as guest speaker in NFRG weekly lab talk

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(pub. 30/10/217)

New paper for Dr. Marina Garcia Macia

"System-wide Benefits of Intermeal Fasting byAutophagy" published in Cell Metabolism. Dr Marina Garcia Macia as co-author.

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(pub. 27/10/2017)

Jack Leslie's poster in AASLD Liver Meeting 2017

"cRel controls epithelial reprogramming to promote hepatic fibrosis and tissue regeneration"

View the poster

(pub. 23/10/2017)

Nuformix announces anti-fibrotic compound study with NFRG's Fibrofind

Nuformix has entered into an agreement with Fibrofind to conduct pre-clinical development work for its NXP002 programme.

Read more on Nuformix's website

New Article approved by the Journal of Epigenetics

A new NFRG paper, issued from a collaborative study with Icahn School of Medicine at Mount Sinai New York, has been accepted by The journal of Epigenetics.

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New NFRG poster presented at the International Workshop on Scleroderma Research

Dr Julie Worrell presented her new abstract and poster entitled Regulation of fibroblast phenotype, functionality and matrix production by the NF-KB subunit c-REL in fibrosis at the International Workshop on Scleroderma Research

View article

New NFRG Publication in Nature Communication

A newly published paper with Prof. Derek Mann's participation has been published in Nature Communication. It describes how cell senescence promotes steatosis in the ageing liver

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New Publication in Cell Death & Disease

NFRG members Prof. Derek Mann, Prof. Fiona Oakley and Dr. Caroline Wilson have been collaborating on this new paper which describes functions for the p50 subunit of NF-kB in kidney damage.

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New publication out of cooperation with French company Inventiva

Prof. Derek Mann and Prof. Fiona Oakley have seen the results of an active cooperation with French company Inventiva published in a new paper on a new drug tested for its ability to protect the liver from fibrosis in NAFLD.

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