News

Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites—Halogenated Probes of Druglike and Peptide-like Molecular Interactions

Last modified: Mon, 19 Dec 2022 17:34:39 GMT

New Paper – Generation of lead-like libraries with scaffold diversity

Build−Couple−Transform: A Paradigm for Lead-like Library Synthesis with Scaffold Diversity

Last modified: Mon, 19 Dec 2022 17:14:31 GMT

Jessica Graham wins at Sygnature Postgraduate Symposium

Medicinal Chemistry PhD student, Jess Graham, wins award for her flash presentation at the Sygnature Postgraduate Symposium.

Last modified: Mon, 01 Aug 2022 09:02:27 BST

Researchers go on the run to raise funds

Scientists at the Cancer Research UK Drug Discovery Unit in Newcastle are going on the run to raise funds for life-saving research and are urging others to do the same.

Last modified: Fri, 08 Jul 2022 15:57:45 BST

Prestigious EFMC Award for Prof. Mike Waring

UCB-Ehrlich Award for Excellence in Medicinal Chemistry is awarded to Mike Waring

Last modified: Tue, 24 May 2022 16:57:57 BST

New Paper – Discovery of ERK5 Kinase Domain Inhibitors

Parallel Optimisation of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor

Last modified: Mon, 19 Dec 2022 17:15:28 GMT

New Paper - DNA-compatible SNAr reactions

Scope of on-DNA nucleophilic aromatic substitution on weakly-activated heterocyclic substrates for the synthesis of DNA-encoded libraries.

Last modified: Mon, 19 Dec 2022 17:16:26 GMT

STEM for BRITAIN 2022

Harriet Stanway-Gordon chosen to present her PhD work at the prestigious STEM for BRITAIN event at the Houses of Parliament.

Last modified: Thu, 31 Mar 2022 14:37:04 BST

Success for Jess at RSC Postgraduate Symposium

Medicinal Chemistry PhD student, Jessica Graham, wins award for her poster presentation at the RSC BMCS Postgraduate Symposium XV

Last modified: Mon, 13 Dec 2021 20:53:26 GMT

New Paper – Expanding the scope of Suzuki−Miyaura cross-couplings for DELs

Functional group tolerance of a micellar on-DNA Suzuki−Miyaura cross-coupling reaction for DNA-encoded library design.

Last modified: Mon, 19 Dec 2022 17:17:34 GMT

New Paper - Micellar Buchwald-Hartwig couplings for DELs

Micellar Buchwald–Hartwig Coupling of Aryl and Heteroarylamines for the Synthesis of DNA-Encoded Libraries

Last modified: Wed, 30 Mar 2022 10:58:54 BST

New Paper - On-DNA Hydrogenolysis and Hydrogenation

On-DNA Transfer Hydrogenolysis and Hydrogenation for the Synthesis of DNA-Encoded Chemical Libraries.

Last modified: Mon, 19 Dec 2022 17:18:57 GMT

New Paper - Convenient and efficient synthesis of 4-oxo-2-butenoic acids

Microwave-assisted synthesis of 4-oxo-2-butenoic acids by aldol-condensation of glyoxylic acid.

Last modified: Mon, 19 Dec 2022 17:20:09 GMT

CRUK Race for Life 2021

Newcastle researchers take part in CRUK Race for Life

Last modified: Wed, 10 Nov 2021 11:41:08 GMT

Harriet Stanway-Gordon wins EPSRC Doctoral Prize Fellowship

SNES Medicinal Chemistry PhD student Harriet Stanway-Gordon has won an EPSRC doctoral prize fellowship to further develop work carried out as part of her PhD.

Last modified: Tue, 16 Nov 2021 08:18:37 GMT

Success for Alex Hallatt at SAgE Faculty Postgraduate Researcher Conference

Medicinal Chemistry PhD student, Alex Hallatt, wins award for his presentation at the SAgE Faculty Postgraduate Research Conference 2021.

Last modified: Mon, 12 Jul 2021 15:20:16 BST

Alex Hallatt wins at RSC Postgraduate Symposium

Alex Hallatt wins at RSC Chemical Biology & Bio-Organic Group Postgraduate Symposium 2021

Last modified: Mon, 12 Jul 2021 15:19:16 BST

New Paper – Irreversible inhibitors of NIK

Alkynyl-heterocyclic warheads as useful covalent binding warheads

Last modified: Mon, 19 Dec 2022 17:21:09 GMT

New Paper - New developments in the chemistry for DNA-encoded library synthesis

Highly efficient on-DNA amide couplings for DNA-encoded library synthesis

Last modified: Mon, 19 Dec 2022 17:22:09 GMT

New Review – Design of DNA-encoded libraries

An Analysis of Published DNA-Encoded Libraries for Key Design ‘Take Homes’

Last modified: Mon, 19 Dec 2022 17:23:02 GMT

New Paper - Structure-based design of MDM2 inhibitors

Structure-based optimisation of isoindolinone leads into potent MDM2-p53 inhibitors

Last modified: Mon, 19 Dec 2022 17:24:58 GMT

New Paper – Facile synthesis of poly-substituted aminopyrimidines

The facile synthesis of highly desirable polysubstituted aminopyrimidines is described.

Last modified: Mon, 19 Dec 2022 17:25:58 GMT

New Review – DNA-encoded libraries for first-time users

The maturation of DNA-encoded libraries: opportunities for new users

Last modified: Mon, 19 Dec 2022 17:26:45 GMT

ELRIG Drug Discovery Digital 2020

Dr Natalie Tatum presents FragLites work at ELRIG Drug Discovery Digital 2020

Last modified: Fri, 16 Oct 2020 11:05:27 BST

Harriet Stanway-Gordon wins at SAgE Faculty Celebration of Research

Medicinal Chemistry PhD student Harriet Stanway-Gordon wins two awards for her presentation on DNA-Encoded Libraries at the SAgE Faculty Postgraduate Research Conference.

Last modified: Fri, 12 Jun 2020 11:54:32 BST

New Paper – Screening the COVID-19 main protease

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

Last modified: Mon, 19 Dec 2022 17:27:35 GMT

New Paper – Irreversible Inhibitors of Nek2 Kinase

2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase

Last modified: Mon, 19 Dec 2022 17:32:24 GMT

New Review – Structure and function in human cyclin proteins

In this review, the authors survey available structures of human cyclins, highlighting their molecular features in the context of their cellular roles.

Last modified: Mon, 19 Dec 2022 17:30:04 GMT

Dr Natalie Tatum wins inaugural CoSeC Impact Award, 2020

Dr Natalie Tatum of the Cancer Research UK Newcastle Drug Discovery Unit wrote the winning application for her work on antimicrobial resistance.

Last modified: Tue, 19 May 2020 20:54:19 BST

Newcastle researchers successfully complete Race for Life at Home challenge

Researchers in the CRUK Newcastle Drug Discovery Group set out to run, walk and cycle 1000 miles. Having completed a virtual tour of the 5 CRUK Drug Discovery Units in 4 days, the group decided to go for two laps and completed 2000 miles.

Last modified: Thu, 14 May 2020 19:19:23 BST

Newcastle researchers 1,000 mile at home challenge to fight cancer

Scientists across the cancer research community in Newcastle are joining forces to carry on the fight against the disease as part of the Cancer Research UK Race for Life at Home challenge.

Last modified: Wed, 06 May 2020 09:01:57 BST

New Paper - DELs in micelles

High Fidelity Suzuki–Miyaura Coupling for the Synthesis of DNA Encoded Libraries Enabled by Micelle Forming Surfactants

Last modified: Mon, 19 Dec 2022 17:29:12 GMT

We are contributing to discovery of new drugs to combat COVID-19

Using fragment-based drug design to contribute compounds that inhibit the COVID-19 main protease, an initiative that is being led by Diamond Light Source.

Last modified: Mon, 27 Apr 2020 14:05:19 BST

Cancer Research UK Chief Executive Michelle Mitchell Visits Newcastle

Cancer Research UK Chief Executive Michelle Mitchell visits Newcastle University Centre for Cancer

Last modified: Thu, 27 Feb 2020 14:01:06 GMT

BALVERSA™ (erdafitinib) approved for advanced or metastatic urothelial carcinoma

Erdafitinib, an oral pan-FGFR inhibitor discovered thorough collaboration between Newcastle University, Astex Pharmaceuticals and Janssen Pharmaceutica, has been approved for treatment

Last modified: Wed, 05 Feb 2020 13:12:37 GMT

Nobel Laureate Prof. Richard Henderson visited Newcastle

Professor Richard Henderson, recipient of the Nobel Prize in Chemistry in 2017 for his work in the field of cryo-electron microscopy, visited Newcastle on Tuesday 5th March 2019

Last modified: Mon, 17 Feb 2020 17:01:28 GMT

Prof. Herbie Newell awarded CBE in New Year's Honours List

Professor Herbie Newell, Emeritus Professor of Cancer Therapeutics and a founder of Newcastle Drug Discovery, was awarded a CBE for services to Medical Research and Drug Development in the 2019 New Year's Honours List

Last modified: Wed, 05 Feb 2020 13:13:38 GMT

Prof. Herbie Newell recipient of Malcolm Campbell Memorial Prize 2019

Professor Herbie Newell, Emeritus Professor of Cancer Therapeutics and a founder of Newcastle Drug Discovery, was named as a recipient of the Malcolm Campbell Memorial Prize 2019 representing the NICR in the discovery of erdafitinib.

Last modified: Wed, 05 Feb 2020 13:13:51 GMT