New Review – Design of DNA-encoded libraries

On the design of lead-like DNA-encoded chemical libraries 

Bioorg. Med. Chem., 2021, 43, 116273

https://www.sciencedirect.com/science/article/pii/...

https://doi.org/10.1016/j.bmc.2021.116273

Isaline F.S.F. Castan, Jessica S. Graham, Catherine L.A. Salvini, Harriet A. Stanway-Gordon, Michael J. Waring*

DNA-encoded libraries (DELs) are becoming an established technology for finding ligands for protein targets. We have abstracted and analysed libraries from the literature to assess the synthesis strategy, selections of reactions and monomers and their propensity to reveal hits. DELs have led to hit compounds across a range of diverse protein classes. The range of reactions and monomers utilised has been relatively limited and the hits are often higher in molecular weight than might be considered ideal. Considerations for future library designs with reference to chemical diversity and lead-like properties are discussed.

Last modified: Mon, 19 Dec 2022 17:23:02 GMT