New Publication - Micelle-Mediated Synthesis

Science of Synthesis: DNA-Encoded Libraries, (2024) 1, 427.

DOI: 10.1055/sos-SD-241-00187

https://science-of-synthesis.thieme.com/app/text/SD-241-00187/17684062609304109464.pdf

Jessica S. Graham, Harriet A. Stanway-Gordon and Michael J. Waring*

Solution-phase DNA-compatible chemistry has typically been restricted to aqueous media due to the solubility requirements of the oligonucleotide tag. This necessity has often limited the types of transformations that can be achieved within DNA-encoded libraries (DELs), and also the scope of building blocks that can be employed. Micelle-forming surfactants have been successfully employed within the field of green chemistry to allow for organic reactions to be conducted within aqueous systems. The application of such technologies for DNA-compatible chemistry thus shows significant promise in overcoming various issues previously exhibited in DEL synthesis, allowing for the generation of libraries with vastly improved chemical diversity.

Following invitation to contribute to the Science of Synthesis volume entitled ‘DNA-Encoded Libraries’ (ed. J. Scheuermann & Y. Li), Jess, Harriet and Mike reviewed applications of micellar-mediated synthesis for DELs, including summaries of current methods for their construction. The implementation of this strategy allows for highly efficient transformations to be achieved across a broad range of substrates within each reaction class, marking an advantageous addition to on-DNA chemistry.

The volume is comprehensive, covering key concepts and technologies focused on DELs and is extremely timely, considering the relevance that DELs have gained both in academia and industry.

Last modified: Wed, 15 May 2024 14:26:59 BST