New Review – DNA-encoded libraries for first-time users

The maturation of DNA-encoded libraries: opportunities for new users

Daniel Conole, James H Hunter, Michael J Waring

Future Medicinal Chemistry, 2021, 13, 173-191

https://www.future-science.com/doi/full/10.4155/fmc-2020-0285

https://doi.org/10.4155/fmc-2020-0285

DNA-encoded combinatorial libraries (DECLs) represent an exciting new technology for high-throughput screening, and are gaining widespread interest within the drug discovery community. 

Historically, DECLs have been the domain of specialised academic groups and industry; however, there has recently been a shift toward more academic centres and institutes adopting this technology. Key to this development has been the simplification, characterization and standardization of various DECL subprotocols, such as library design, affinity screening and data analysis of hits. 

Challenges in this technology continue to be around the availability of on-DNA compatible chemistries; however, developing physiologically relevant affinity screening techniques, particularly for challenging drug targets, remains arduous. 

This review examines the feasibility of implementing DECL screening technology as a first-time user, particularly in academia, exploring the some important considerations for this, and outlines some applications of the technology that academia could contribute to the field.

Last modified: Mon, 19 Dec 2022 17:26:45 GMT