Teresa Borrello

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Dr M. Teresa Borrello

Role: Postdoctoral Research Associate Email: teresa.borrello@newcastle.ac.uk

About

I am a Pharmacist and a Medicinal Chemist with an academic background in Epigenetic drug Discovery and Biological sciences having trained at University of East Anglia (UEA) under supervision of Prof. Ganesan and as a Research scientist at Centre de recherche en Cancerologie de Marseille (CRCM), under supervision of Prof. Juan Iovanna.

My Research focuses on understanding the signalling pathways leading to fibrosis and particularly on protein called Nuclear Protein 1. NUPR1 is a stress response protein overexpressed upon cell injury in virtually all organs including the liver. Despite NUPR1's well-established role in the response to cell stress, the molecular and structural machineries triggered by NUPR1 activation remain largely debated. The work I am conducting in the Fibrosis research group aims to uncover the roles of NUPR1 in the context of liver injury and particularly in the activation of Hepatic Stellate Cells, which is the most important event in the initiation of the fibrotic process.

My other research projects involve the delineation of epigenetic signalling pathways that trigger fibrogenesis and uncover the molecular controls that can be targeted with drugs.

All these research effort have the final goal to tackle fibrosis with new pharmacological approaches.

Major Publications

  • Synthesis of Carboxamide-Containing Tranylcypromine Analogues as LSD1 (KDM1A) Inhibitors Targeting Acute Myeloid Leukemia. Borrello Maria Teresa, Benelkebir H, Lee A, Hin Tam C, Shafat M, Rushworth SA, Bowles KM, Douglas L, Duriez PJ, Bailey S, Crabb SJ, Packham G, Ganesan A. ChemMedChem. 2021 Apr 20;16(8):1316-1324. doi: 10.1002/cmdc.202000754. Epub 2021 Feb 3. PMID: 33533576
  • Loss of activating transcription factor 3 prevents KRAS-mediated pancreatic cancer. Azizi N, Toma J, Martin M, Khalid MF, Mousavi F, Win PW, Borrello MT, Steele N, Shi J, di Magliano MP, Pin CL. Oncogene. 2021 Apr;40(17):3118-3135. doi: 10.1038/s41388-021-01771-z. Epub 2021 Apr 16. PMID: 33864001
  • NUPR1 interacts with eIF2α and is required for resolution of the ER stress response in pancreatic tissue. Borrello MT, Santofimia-Castaño P, Bocchio M, Listi A, Fraunhoffer N, Soubeyran P, Chevet E, Pin C, Iovanna J. FEBS J. 2021 Jan 6. doi: 10.1111/febs.15700. Online ahead of print. PMID: 33403797
  • NUPR1 protects liver from lipotoxic injury by improving the endoplasmic reticulum stress response. Borrello MT, Rita Emma M, Listi A, Rubis M, Coslet S, Augello G, Cusimano A, Cabibi D, Porcasi R, Giannitrapani L, Soresi M, Pantuso G, Blyth K, Montalto G, Pin C, Cervello M, Iovanna J. FASEB J. 2021 Mar;35(3):e21395. doi: 10.1096/fj.202002413RR. PMID: 33566371
  • Evidencing a Pancreatic Ductal Adenocarcinoma Subpopulation Sensitive to the Proteasome Inhibitor Carfilzomib. Fraunhoffer NA, Abuelafia AM, Bigonnet M, Gayet O, Roques J, Telle E, Santofimia-Castaño P, Borrello MT, Chuluyan E, Dusetti N, Iovanna J. Clin Cancer Res. 2020 Oct 15;26(20):5506-5519. doi: 10.1158/1078-0432.CCR-20-1232. Epub 2020 Jul 15. PMID: 32669378
  • Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity. Lecointre B, Narozny R, Borrello MT, Senger J, Chakrabarti A, Jung M, Marek M, Romier C, Melesina J, Sippl W, Bischoff L, Ganesan A. Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748):20170364. doi: 10.1098/rstb.2017.0364. PMID: 29685969 Free PMC article.
  • Fluorinated tranylcypromine analogues as inhibitors of lysine-specific demethylase 1 (LSD1, KDM1A). Borrello MT, Schinor B, Bartels K, Benelkebir H, Pereira S, Al-Jamal WT, Douglas L, Duriez PJ, Packham G, Haufe G, Ganesan A. Bioorg Med Chem Lett. 2017 May 15;27(10):2099-2101. doi: 10.1016/j.bmcl.2017.03.081. Epub 2017 Mar 29. PMID: 28390942 Free article.
  • cis-Cyclopropylamines as mechanism-based inhibitors of monoamine oxidases. Malcomson T, Yelekci K, Borrello MT, Ganesan A, Semina E, De Kimpe N, Mangelinckx S, Ramsay RR. FEBS J. 2015 Aug;282(16):3190-8. doi: 10.1111/febs.13260. Epub 2015 Mar 27. PMID: 25755053 Free article.
  • Expanding the druggable space of the LSD1/CoREST epigenetic target: new potential binding regions for drug-like molecules, peptides, protein partners, and chromatin. Robertson JC, Hurley NC, Tortorici M, Ciossani G, Borrello MT, Vellore NA, Ganesan A, Mattevi A, Baron R. PLoS Comput Biol. 2013;9(7):e1003158. doi: 10.1371/journal.pcbi.1003158. Epub 2013 Jul 18. PMID: 23874194 Free PMC article.
  • Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase. Tortorici M, Borrello MT, Tardugno M, Chiarelli LR, Pilotto S, Ciossani G, Vellore NA, Bailey SG, Cowan J, O'Connell M, Crabb SJ, Packham G, Mai A, Baron R, Ganesan A, Mattevi A. ACS Chem Biol. 2013 Aug 16;8(8):1677-82. doi: 10.1021/cb4001926. Epub 2013 Jun 11. PMID: 23721412
  • Efficient synthesis and biological evaluation of proximicins A, B and C. Brucoli F, Natoli A, Marimuthu P, Borrello MT, Stapleton P, Gibbons S, Schätzlein A. Bioorg Med Chem. 2012 Mar 15;20(6):2019-24. doi: 10.1016/j.bmc.2012.01.043. Epub 2012 Feb 4. PMID: 22364744
  • Structural characterization and antimicrobial evaluation of atractyloside, atractyligenin, and 15-didehydroatractyligenin methyl ester. Brucoli F, Borrello MT, Stapleton P, Parkinson GN, Gibbons S.J. Nat Prod. 2012 Jun 22;75(6):1070-5. doi: 10.1021/np300080w. Epub 2012 May 17.PMID: 22594797