Emma ScottRole: PhD Student Email: E.Scott4@newcastle.ac.uk
In 2015 I completed an integrated Masters in Genetics at the University of Liverpool. Here I undertook a research project in the North West Cancer Research Institute entitled 'The effect of mild temperature hyperthermia on DNA repair pathways in high-risk human papillomavirus positive head and neck squamous cell carcinoma'. Having thoroughly enjoyed this experience I then decided to complete a PhD.
In October 2015 I began my PhD under the supervision of Professor Quentin Anstee, Professor Ann Daly and Dr Jeremy Palmer, working on the Elucidating Pathways of Steatohepatitis (EPoS) project. The title of my PhD is 'The genomic and functional characterisation of TM6SF2 and its association with progressive non-alcoholic fatty liver disease'. NAFLD refers to a spectrum of hepatic disorders which are characterised by the accumulation of excess fat in the liver, ranging from simple steatosis to cirrhosis. Several genetic modifiers of NAFLD have been identified, including TM6SF2. A gene variant in the TM6SF2 gene (E167K) has been identified as a modifier of steatosis and associated with advanced fibrosis in NAFLD patients.The aim of my PhD is to explore the mechanistic role of TM6SF2 and the E167K genetic variant and its role in progressive NAFLD.
- MBiolSci (Genetics), University of Liverpool, 2015.