Nick Kalson
About
I am a surgeon interested in musculoskeletal health and disease. I graduated in medicine from Manchester University in July 2012. I combined my medical degree with scientific training in the Wellcome Trust Centre for Cell Matrix Research, where I worked on collagen fibril assembly, earning my PhD under the supervision of Professor Karl Kadler.
I then worked in London for two years to complete my junior doctor training before moving to Newcastle in August 2014 to take up a combined clinical-academic training post in Trauma and Orthopaedic Sugery (Academic Clinical Fellowship). During the ACF I began working with Dr Lee Borthwick (Fibrosis Research Group PI) investigating the cellular/molecular mechanisms underlying joint fibrosis that follows trauma or surgery (such as total knee replacement). We now have both clinical and basic research studies underway that attempt to provide mechanistic insight into this challenging clinical problem. The ultimate aim of our research work is to identify anti-fibrotic agents that are clinically useful in fibrotic, painful, scarred joints.
In 2017 I took up an NIHR Academic Clinical Lecturer post which I will use to work in the Fibrosis Group whilst continuing my clinical training in orthopaedic surgery.
Education
- MRCS (Member of the Royal College of Surgeons, Edinburgh and Glasgow) - 2015
- PG Diploma in Clinical Research, University of Newcastle, UK - 2015
- MB-PhD program, University of Manchester, UK - 2003-2012
- MBChB (Hons) - 2012
- PhD in Developmental Biology - Thesis title: The role of cell-generated force in tendon development - 2008-2012
- Intercalated BSc (Hons) Pathology, 1st Class, University of Manchester, UK - 2005-2006
Major Publications
Knee joint fibrosis
- Kalson NS, Borthwick LA, Mann DA, Deehan DJ, Lewis P, Mann C, Mont MA, Morgan-Jones R, Oussedik S, Williams FM, Toms A, Argenson JN, Bellemans J, Bhave A, Furnes O, Gollwitzer H, Haddad FS, Hofmann S, Krenn V. - International consensus on the definition and classification of fibrosis of the knee joint (2016).
- Dixon D, Coates J, del Carpio Pons A, Horabin J, Walker A, Abdul N, Kalson NS, Brewster NT, Weir DJ, Deehan DJ, Mann DA, Borthwick LA - A potential mode of action for Anakinra in patients with arthrofibrosis following total knee arthroplasty (2015).
- Williams FM, Kalson NS, Fabiane SM, Mann DA, Deehan DJ - Joint Stiffness Is Heritable and Associated with Fibrotic Conditions and Joint Replacement (2015).
Basic science research
- Taylor SH*, Yeung CY, Kalson NS, Lu Y, Zigrino P, Starborg T, Warwood S, Holmes DF, Canty-Laird EG, Mauch C, Kadler KE - Matrix metalloproteinase 14 is required for fibrous tissue expansion (2015).
- Kalson NS, Lu Y, Taylor SH, Starborg T, Holmes DF, Kadler KE - A structure-based extracellular matrix expansion mechanism of fibrous tissue growth (2015).
- Kalson NS, Starborg T, Lu Y, Humphries SM, Holmes DF, Kadler KE - Non-muscle myosin II powered transport of newly-formed collagen fibrils at the plasma membrane (2013).
- Starborg T, Kalson NS, Lu Y, Mironov A, Cootes TF, Holmes DF, Kadler KE - Using transmission electron microscopy and 3View to determine collagen fibril size and three-dimensional organization (2013).
- Herchenhan A, Kalson NS, Holmes DF, Hill P, Kadler KE, Margetts L - Tenocyte contraction induces crimp formation in tendon-like tissue (2012).
- Kalson NS, Holmes DF, Herchenhan A, Lu Y, Starborg T, Kadler KE - Slow stretching that mimics embryonic growth rate stimulates structural and mechanical development of tendon-like tissue in vitro (2011).
- Kalson NS, Holmes DF, Kapacee Z, Otermin I, Lu Y, Ennos RA, Canty-Laird EG, Kadler KE - An experimental model for studying the biomechanics of embryonic tendon: Evidence that the development of mechanical properties depends on the actinomyosin machinery (2010).
Clinical surgical research
- Molina AR, Chatterton BD, Kalson NS, Fallowfield ME, Khandwala AR - Multiple schwannomas of the upper limb related exclusively to the ulnar nerve in a patient with segmental schwannomatosis (2013).
- Malone PS, Hutchinson CE, Kalson NS, Twining CJ, Terenghi G, Lees VC - Subluxation-related ulnar neuropathy (SUN) syndrome related to distal radioulnar joint instability (2012).
- Kalson NS, Malone PS, Bradley RS, Withers PJ, Lees VC - Fibre bundles in the human extensor carpi ulnaris tendon are arranged in a spiral (2012).
- Kalson NS, Jenks T, Woodford M, Lecky FE, Dunn KW - Burns represent a significant proportion of the total serious trauma workload in England and Wales (2012).
- Kalson NS, Dunn KW - Contribution to national acute injury and intensive care audit databases in England and Wales (2011).
- Kalson NS, Geoghegan JM, Funk L. Shoulder & Elbow - Destructive synovial hemangioma of the hip resembling pigmented villonodular synovitis (2011).
- Kalson NS, Gikas PD, Aston W, Miles J, Blunn G, Pollock R, Skinner J, Briggs TW, Cannon SR - Custom-made endoprostheses for the femoral amputation stump: an alternative to hip disarticulation in tumour surgery (2010).
- Bharathi RR, Jerome JT, Kalson NS, Sabapathy SR - V-Y advancement flap coverage of toe-tip injuries (2009).
- Kalson NS, Mulgrew E, Cook G, Lovell ME - Does the number of trauma lists provided affect care and outcome of patients with fractured neck of femur? (2009).
- Kalson NS, Charalambous CP, Powell ES, Hearnden A, Stanley JK - Tendon graft--ulna fixation in distal radio-ulnar joint stabilisation; biomechanical comparison of three graft-bone fixation methods (2009).
- Gikas PD, Hanna SA, Aston W, Kalson NS, Tirabosco R, Saifuddin A, Cannon SR - Post-radiation sciatic neuropathy: a case report and review of the literature (2008).
High altitude research
- Davies AJ, Morris DS, Kalson NS, Wright AD, Imray CH, Hogg CR - Changes to colour vision on exposure to high altitude (2011).
- Kalson NS, Hext F, Davies AJ, Chan CW, Wright AD, Imray CH - Do changes in gastro-intestinal blood flow explain high-altitude anorexia? (2010)
- Stokes S, Kalson NS, Earl M, Whitehead AG, Tyrrell-Marsh I, Frost H, Davies A - Age is no barrier to success at very high altitudes (2010).
- Davies AJ, Kalson NS, Stokes S, Earl MD, Whitehead AG, Frost H, Tyrell-Marsh I, Naylor J - Determinants of summiting success and acute mountain sickness on Mt Kilimanjaro (5895 m) (2009).
- Stokes SH, Kalson NS, Frost H, Tyrrell-Marsh I, Whitehead AG, Davies A, Earl M - Adolescents with altitude: young people do well on Kilimanjaro (2009).
- Kalson NS, Thompson J, Davies AJ, Stokes S, Earl MD, Whitehead A, Tyrrell-Marsh I, Frost H, Montgomery H - The effect of angiotensin-converting enzyme genotype on acute mountain sickness and summit success in trekkers attempting the summit of Mt. Kilimanjaro (5,895 m) (2009).
- Stokes S, Kalson NS, Earl M, Frost H, Whitehead AG, Tyrrell-Marsh I, Davies A - Bronchial asthma on Mount Kilimanjaro is not a disadvantage (2008).
- Kalson NS, Davies AJ, Stokes S, Frost H, Whitehead AG, Tyrrell-Marsh I, Earl MD - Climbers with diabetes do well on Mount Kilimanjaro (2007).