Jelena Mann

Dr._Jelena_Mann Social Media

Prof Jelena Mann

Role: Professor in Epigenetics Email: jelena.mann@newcastle.ac.uk

About

Liver fibrosis is a final common pathway of liver injury irrespective of aetiology. It is characterised by progressive replacement of normal hepatic tissue with collagen-rich scar tissue and is responsible for around 1.5 million death per annum worldwide. There are no proven effective therapeutics for fibrosis, the only treatment available for chronic liver disease is transplantation which is limited by availability of donor organs. 

I am interested in delineating epigenetic signalling pathways that trigger fibrogenesis and in doing so, discovering molecular control of fibrogenesis and associated signalling pathways that can be targeted with new as well as existing drugs. More recently we have also embarked on studies that test the ability of environmental factors to affect transgenerational inheritance of predisposition to liver fibrosis. Adaptation to environmental insults is critical for ensuring fitness and survival of the species, however it is currently not clear if predisposition to development of fibrosis exists or indeed if existence of disease in previous generations alters such predisposition.

We have published the first report of the transgenerational epigenetic transmission of protection against liver fibrosis which provides evidence of heritable mechanisms for the rapid adaptation of animals to environmental insults. The lab is now carrying out further characterisation of this newly reported phenomena and its impact on liver disease of various aetiology.

Education

  • 1994-1997 - BSc Biochemistry, 1st class
  • 1997-2001 - PhD in Medicine, University of Southampton

Previous appointments

  • University of Leeds, Postdoctoral Research Assistant (31/01/2001 to 31/12/2002)
  • Wellcome Trust Postdoctoral Research Assistant, University of Southampton (01/01/2003 to 31/08/2004).
  • University of Southampton Personal Fellowship 01/09/2004 to 01/10/2006

Memberships

  • Member of the British Association for the Study of Liver Disease
  • Member of the European Association for the Study of Liver Disease

Editorial boards

  • Journal of Hepatology

Prizes

  • Best talk prize, British Association for study of liver annual meeting, 2007
  • Best abstract prize, British Association for study of liver annual meeting, 2008
  • September 2010, Dame Sheila Sherlock Young Investigator Research Medal - single annual award for outstanding research contributions in the field of Hepatology

Patents

  • United Statesprovisional application serial nos. US61/206,774, filed February 4, 2009, entitled "Methods of Inhibiting Liver Fibrogenesis and Treating Liver Damage, Including Cirrhosis of the Liver" and 61/277,284, filed September 22, 2009, entitled "Methods of Inhibiting Fibrogenesis and Treating Fibrotic Disease"

Major Publications