Newcastle Fibrosis Research Group

Newcastle Fibrosis Research Group

The Newcastle Fibrosis Research Group is a top-level multi-disciplinary research group of Newcastle University highly experienced in the underlying mechanisms of fibrosis in liver, lung, kidney, heart, skin and joints.

Our Research

Public Engagement

As part of a higher education institution, engaging ourselves with society is a key priority. Fibrotic diseases involve complex mechanisms which we think should be understandable by everyone. Teaching and wide diffusion knowledge about Fibrosis is one of our leading missions.

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News & Events

Nuformix announces anti-fibrotic compound study with NFRG's Fibrofind

Nuformix has entered into an agreement with Fibrofind to conduct pre-clinical development work for its NXP002 programme.

Read more on Nuformix's website
New paper accepted by the Journal of Epigenetics

Issued from a collaborative study with @Icahn School of Medicine at Mount Sinai New York, it is entitled "Variant Histone H2afv Reprograms DNA Methylation During Early Zebrafish Development"

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New poster at the International Workshop on Scleroderma Research

Dr Julie Worrell has presented her new abstract and poster entitled Regulation of fibroblast phenotype, functionality and matrix production by the NF-KB subunit c-REL in fibrosis at the International Workshop on Scleroderma Research held in Pittsburgh in August 2017

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New NFRG Publication in Nature Communication

A newly published paper with Prof. Derek Mann's participation has been published in Nature Communication. It describes how cell senescence promotes steatosis in the ageing liver

Read it on PubMed
New Publication in Cell Death & Disease

NFRG members Prof. Derek Mann, Prof. Fiona Oakley and Dr. Caroline Wilson have been collaborating on this new paper which describes functions for the p50 subunit of NF-kB in kidney damage.

Read it on PubMed
New publication out of cooperation with French company Inventiva

Prof. Derek Mann and Prof. Fiona Oakley have seen the results of an active cooperation with French company Inventiva published in a new paper on a new drug tested for its ability to protect the liver from fibrosis in NAFLD.

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