Prof. Jelena Mann

Publications - Prof. Jelena Mann

Rapamycin improves healthspan but not inflammaging in nfκb1 -/- mice. View >
Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence. View >
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis. View >
A Bioreactor Technology for Modeling Fibrosis in Human and Rodent Precision‐Cut Liver Slices. View >
Ammonia scavenging prevents progression of fibrosis in experimental non-alcoholic fatty liver disease. View >
Systemic inflammation contributes to impairment of quality of life in chronic pancreatitis. View >
Fibrogenic Activity of MECP2 is Regulated by Phosphorylation in Hepatic Stellate Cells. View >
cRel Expression Regulates Distinct Transcriptional and Functional Profiles Driving Fibroblast Matrix Production in Systemic Sclerosis. View >
Epigenetic mechanisms and metabolic reprogramming in fibrogenesis: Dual targeting of G9a and DNMT1 for the inhibition of liver fibrosis. View >

Plasma cell-free DNA methylation: a liquid biomarker of hepatic fibrosis. View >
Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage View >
HDAC1 interacts with the p50 NF-κB subunit via its nuclear localization sequence to constrain inflammatory gene expression. View >
Liquid biopsy for liver diseases. View >

A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A (DZNep) View >
Epigenetics and Liver Fibrosis View >
Variant Histone H2afv reprograms DNA methylation during early zebrafish development. View >

Hepatic Stellate Cell Transdifferentiation Involves Genome-Wide Remodeling of the DNA Methylation Landscape. View >
Plasma DNA Methylation: A Potential Biomarker for Prognostic Stratification of Liver Fibrosis in Non-Alcoholic Fatty Liver Disease View >
Pseudomonas aeruginosa induced airway epithelial injury drives fibroblast activation: a mechanism in chronic lung allograft dysfunction View >
The role of exosomes in the pathogenesis of Pancreatic Ductal Adenocarcinoma". The International Journal of Biochemistry & Cell Biology. View >
DNA methylation profiling identifies novel markers of progression in hepatitis B-related chronic liver disease View >
Dynamic phosphorylation of RelA on Ser42 and Ser45 in response to TNFα stimulation regulates DNA binding View >

NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma View >
Alcohol directly stimulates epigenetic modifications in hepatic stellate cells. View >
The role of pancreatic stellate cells in pancreatic cancer View >
Differential DNA methylation of genes involved in fibrosis progression in non-alcoholic fatty liver disease and alcoholic liver disease. View >
Gain-of-function STAT1 mutations impair STAT3 activity in patients with Chronic Mucocutaneous Candidiasis (CMC) View >

A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. View >
IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts. View >
Quiescent Hepatic Stellate Cells Functionally Contribute to the Hepatic Innate Immune Response via TLR3. View >
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. View >
Arrested development and the great escape--the role of cellular senescence in pancreatic cancer. View >

Tumor progression locus 2/Cot is required for activation of extracellular regulated kinase in liver injury and toll-like receptor-induced TIMP-1 gene transcription in hepatic stellate cells View >
Glucose induces protein targeting to glycogen in hepatocytes by fructose 2,6-bisphosphate-mediated recruitment of MondoA to the promoter. View >
An experimental study to identify the potential role of pharmacogenomics in determining the occurrence of oxaliplatin-induced liver injury. View >
Epigenetic regulation of wound healing and fibrosis. View >
A reversible model for periportal fibrosis and a refined alternative to bile duct ligation. View >
Epigenetic modifications as new targets for liver disease therapies. View >
The potential contribution of tumour-related factors to the development of FOLFOX-induced sinusoidal obstruction syndrome. View >
Pathogenesis of FOLFOX induced sinusoidal obstruction syndrome in a murine chemotherapy model. View >

The Histone Methyltransferase ASH1 Orchestrates Fibrogenic Gene Transcription During Myofibroblast Transdifferentiation View >
Multigenerational Epigenetic Adaptation of the Hepatic Wound-Healing Response View >
Rosmarinic acid and baicalin epigenetically de-repress Pparγ in hepatic stellate cells for their anti-fibrotic effect. View >
The NF-κB subunit c-Rel stimulates cardiac hypertrophy and fibrosis View >
Cross-talk between DNA methylation and histone modifications regulates expression of the CLL prognostic marker ZAP-70 View >
Telomeres are favored targets of a persistent DNA damage response in ageing and stress-induced senescence. View >

Stimulating healthy tissue regeneration by targeting the 5-HT(2B) receptor in chronic liver disease. View >
Epigenetic cell fate regulation of hepatic stellate cells. View >

MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis. View >
The NF-κB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple proinflammatory genes. View >
The c-Rel subunit of nuclear factor-kappaB regulates murine liver inflammation, wound-healing, and hepatocyte proliferation. View >
Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis. View >
Allele-specific regulation of matrix metalloproteinase-3 gene by transcription factor NFkappaB. View >
Regulation of NF-κB responses by epigenetic suppression of IκBα expression in HCT116 intestinal epithelial cells View >
Epigenetic downregulation of human Disabled-2 switches TGF-beta from a tumor suppressor to a tumor promoter. View >
Low strength T-cell activation promotes Th17 responses. View >
The NF-kappaB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes. View >

Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis View >
Pharmacological inhibitors of NF-kappaB accelerate apoptosis in chronic lymphocytic leukaemia cells. View

JunD regulates transcription of the tissue inhibitor of metalloproteinases-1 and interleukin-6 genes in activated hepatic stellate cells View >
CD40 induces interleukin-6 gene transcription in dendritic cells: regulation by TRAF2, AP-1, NF-kappa B, AND CBF1. View >
Basal expression of IkappaBalpha is controlled by the mammalian transcriptional repressor RBP-J (CBF1) and its activator Notch1 View >
A failure of transforming growth factor-beta1 negative regulation maintains sustained NF-kappaB activation in gut inflammation View >
Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury. View >
Functional analysis of Human Immunodeficiency Virus Type 1 Nef reveals a role for PAK2 as a regulator of cell phenotype and function in the murine dendritic cell line, DC2.4 View >
JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase (JNK)-independant phosphorylation View >