ESR 5

Large-scale brain networks through primate evolution

Location(s): French National Institute of Health and Medical Research (INSERM), Lyon, France

Supervisors: Dr F Hadj-Bouziane, Dr C Amiez 

Through evolution, the brain has changed both in size and organization with a remarkable preservation of brain rhythms or oscillations. Such brain rhythms have been found at rest, when the subject is not involved in any task or under different states including sleep and anesthesia. However, to date, the organization of neural networks across species remained unclear. This project will analyze resting-state-functional Magnetic Resonance Imaging (rs-fMRI) data in anesthetized non-human primates including marmosets, macaques, baboons, and chimpanzees, as well as in awake macaques and humans. We will focus on the impact of different levels of anesthesia on corticocortical and cortico-subcortical networks to ensure a continuum between knowledge on anesthetized to awake primates. This approach is critical and nicely complements the other ESR projects, as it will help implement the transfer of knowledge from monkeys to humans.

Behavioural paradigm: resting-state. 

Recording and stimulation techniques: fMRI across different species.

Planned secondments: 

  • Covance Preclinical Services GMbH
  • The University of Western Ontario 

Contact: email Dr F Hadj-Bouzianeemail Dr C Amiez 

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