Cortical interactions for processing motion information in marmosets

Location(s): CNRS & Aix-Marseille University, Marseille, France. 

Supervisors: Dr Frédéric Chavane, Dr Lyle Muller

Despite decades of work in the visual system, we still have little understanding on how the visual system process a simple stimulus moving along a long trajectory. The working hypothesis of this PhD is that cortical interactions within and between retinotopic maps are key in the processing of such global motion signals. This, however, necessitates recording tools to visualize retinotopic maps at the scale of whole cortical areas, such as voltage-sensitive dye imaging (VSDI) and multi-electrode arrays (MEA). Using these tools in the awake macaque monkey, we have demonstrated that local, stationary stimuli generate waves propagating in parallel within V1 and V2 retinotopic maps. When presented in succession, these local stimuli generate a complex cascade of embedded intra and inter-cortical propagations that shapes motion representation. However, studying these phenomena in the macaque does not allow observing the dynamics of activity of cortical regions buried in a sulcus (like part of V2, V3 and V5). The objective of this PhD project will be to explore how cortical waves participates in processing motion from V1 to V5 of the lissencephalic marmoset using VSDI but also MEA recordings analyzed through advanced processing methods (in collaboration with ESR1 and 2).

Behavioural paradigm: Eye movements towards the perceived motion direction. 

Recording and stimulation techniques: Voltage-Sensitive Dye Imaging and multi-electrode arrays (ECoG and Utah arrays) in the visual cortex. 

Contact: email Dr Chavane

Planned Secondment:

  • German Primate Center (DPZ)
  • The University of Western Ontario 

Contact: email Dr Chavane 

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