• Early Stage Researcher 15 (ESR 15) name:  Sareer Ahmad

Email address: Sareer.Ahmad@covance.com "OR" sareerneuro95@gmail.com

Personal Information:

I did my Bachelor in field of Biochemistry from Pakistan in 2018, and then I went to South Korea where I completed my Master degree in Neuroscience and my research area was neurodegenerative disease such as Alzheimer's disease, Parkinson, Traumatic brain injury, aging and ischemia models. I explored multiple molecular and cellular pathways which are involved in progressions of neurodegenerative disease and use different flavonoid and polyphenol compound as neuroprotection.

I have wide range of experience both in Vivo and Invitro, and can induce different disease model in mice such as intracerebral ventricular injections of Amyloid beta, Traumatic brain injury, Ischemia model.

I have great command on mice handlings, drug preparation and administration, Behavioral analysis, Western blot, confocal microscopy and cell culturing.

Publications:

Ahmad, S., Khan, A., Ali, W., Jo, M. H., Park, J., Ikram, M., & Kim, M. O. (2021). Fisetin rescues the mice brains against D-galactose-induced oxidative stress, neuroinflammation and memory impairment. Frontiers in Pharmacology, 57.

Ahmad, S., Jo, M. H., Ikram, M., Khan, A., & Kim, M. O. (2021). Deciphering the Potential Neuroprotective Effects of Luteolin against Aβ1–42-Induced Alzheimer’s Disease. International Journal of Molecular Sciences, 22(17), 9583.

Waqar Ali, Muhammad Ikram, Hyun Young Park, Min Gi Jo, Rahat Ullah, Sareer Ahmad, Noman Bin Abid and Myeong Ok Kim. (2020). “Oral Administration of Alpha Linoleic Acid Rescues Aβ-Induced Glia-Mediated Neuroinflammation and Cognitive Dysfunction in C57BL/6N Mice”. The Cell. 9(3); DOI: 10.3390/cells9030667.

Muhammad Sohail Khan, Amjad Khan, Sareer Ahmad, Riaz Ahmad, Inayat Ur Rehman, Muhammad Ikram, and Myeong Ok Kim (2020). “Inhibition of JNK Alleviates Chronic Hypoperfusion-Related ischemia induces Oxidative Stress and Brain Degeneration via Nrf2/HO-1/NF-κB Signaling”. Oxidative Medicine & Cellular longevity. Article ID 5291852; https://doi.org/10.1155/2020/5291852.

Sayed Ibrar Alam, Shafiq Ur Rehman, Rahat Ullah, Tae Ju Park, Min Gi Jo, Sareer Ahmad, Myeong Ok Kim. (2021). ‘‘Quirnpirole-mediated regulation of dopamine D2 receptors inhibits glial cell-induced neuroinflammation in cortex and striatum after brain injury’’. Biomedicine. 9(1); https://doi.org/10.3390/biomedicines9010047.

Tahir ali, Amjad Khan, Sareer Ahmad, Muhammad Ikram, Jun Sung Park, Hyeon Jin Lee and Myeong Ok Kim. (2021). “Cadmium an environmental contaminant exacerbates Alzheimer pathology in the aged mice brain”. Frontier in aging neuroscience.

Amjad Khan, Tae Ju Park, Muhammad Ikram, Tahir Ali, Sareer Ahmad, Riaz Ahmad & Myeong OK Kim*. Anti-oxidative and Anti-Inflammatory effects of Kojic acid in AB-mouse model of Alzheimer’s disease Molecular Neurobiology. Along with this I also receive two "Young pioneer research award".

• Host Institution: Labcorp early development and primate research center 

• Supervisors: Dr D. Smieja, Dr L. Mecklenburg, Prof Dr S. Treue, Prof Dr A. Gail   

• Project title: Development of a novel and comprehensive test panel to evaluate cognitive function for regulatory drug development

• Project description:

"Development/safety assessment of modern and highly targeted human medicines often require NHPs as the relevant animal model. A frequently encountered question from regulatory agencies is whether such medications could have (adverse) effects on brain function – e.g. for compounds that cause brain histologic changes, that are being deposited in the brain or that just cross the blood-brain-barrier. Clinically, cognitive function can be monitored by touch screen based cognitive tests using a CANTAB device. This project aims at developing a behavioral cognitive task panel using MonkeyCANTAB. Project goals are to establish a novel home cage-based testing paradigm, to validate the test panel using compounds that interfere with learning/memory capabilities and to compare test performance in juvenile and adult macaques.

Behavioral paradigm which I used will be; Visual and spatial discrimination, working memory paradigm, self-ordered search, macaques directly interacts with a computer from their home cage."

Contact: email Dr Mecklenburg

More information: 

• Labcorp

• Secondments:

(1) Ludwig-Maximilians University, from 2nd of Nov, 2022 to 2nd of Dec, 2023

In the one-month-long secondment at the Ludwig Maximilian University, Munich, the ESR had a chance to acquire experience in all steps of preparing and performing a computational study, as well as studies related to psychophysics. The knowledge built up during this secondment is extremely relevant to the ESR’s own Ph.D. project. Finally, the secondment in Ludwig university was a great networking opportunity for the ESR to meet fellow researchers both from the hosting lab and from other labs at the Ludwig Maximilian University, München.

(2) Newcastle University (UK), from the 2^nd of April to the 4^th of May, 2023