Prof. Derek Mann

Publications - Prof. Derek Mann FMedSci

2019

TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms. View >
Platelet GP1ba is a mediator and potential interventional target for NASH and subsequent liver cancer. View >
Fibrogenic activity of MeCP2 is regulated by phosphorylation in hepatic stellate cells. View >

2018

Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage. View >
Fibroblasts Promote Inflammation and Pain via IL-1α Induction of the Monocyte Chemoattractant Chemokine (C-C Motif) Ligand 2. View >
Reduced telomere length is associated with fibrotic joint disease suggesting that impaired telomere repair contributes to joint fibrosis. View >
Plasma cell-free DNA methylation: a liquid biomarker of hepatic fibrosis. View >
HDAC1 interacts with the p50 NF-κB subunit via its nuclear localization sequence to constrain inflammatory gene expression. View >

2017

The NF-κB1 is a key regulator of acute but not chronic renal injury. View >
Cellular senescence drives age-dependent hepatic steatosis. View >
The new-generation pan-peroxisome proliferator-activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis. View >
A proof of concept for epigenetic therapy of tissue fibrosis: Inhibition of liver fibrosis progression by 3-deazaneplanocin A. View >
Variant Histone H2afv reprograms DNA methylation during early zebrafish development. View >

2016

Plasma DNA Methylation: A Potential Biomarker for Prognostic Stratification of Liver Fibrosis in Non-Alcoholic Fatty Liver Disease View >
A new fluorescence-based optical imaging method to non-invasively monitor hepatic myofibroblasts in vivo. View
TPL2 Kinase Is a Crucial Signaling Factor and Mediator of NKT Effector Cytokine Expression in Immune-Mediated Liver Injury. View >
A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-κB-dependent liver regeneration and cancer. View >
Mitochondria are required for pro-ageing features of the senescent phenotype. View >
Liver: Osteopontin and HMGB1: novel regulators of HSC activation. View >
Dynamic phosphorylation of RelA on Ser42 and Ser45 in response to TNFa stimulation regulates DNA binding and transcription. View >
Epigenetics in liver disease: from biology to therapeutics. View >
International consensus on the definition and classification of fibrosis of the knee joint. View >
The Role of the Fibroblast in Inflammatory Upper Airway Conditions. View >

2015

NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma. View >
Alcohol directly stimulates epigenetic modifications in hepatic stellate cells. View >
Emerging and disease-specific mechanisms of hepatic stellate cell activation. View >
Epigenetic regulation of liver fibrosis. View >
How reliable are sino-nasal cell lines for studying the pathophysiology of chronic rhinosinusitis? View >
Joint Stiffness Is Heritable and Associated with Fibrotic Conditions and Joint Replacement. View >
Novel therapeutic targets in primary biliary cirrhosis. View >
Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease. View >
Importance of investigating epigenetic alterations for industry and regulators: An appraisal of current efforts by the health and environmental sciences institute. View >
A potential mode of action for Anakinra in patients with arthrofibrosis following total knee arthroplasty. View >
Non-Canonical Wnt Predominates in Activated Rat Hepatic Stellate Cells, Influencing HSC Survival and Paracrine Stimulation of Kupffer Cells. View >

2014

A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. View
Epigenetics in liver disease. View
How reliable are sino-nasal cell lines for studying the pathophysiology of chronic rhinosinusitis? View
Quiescent hepatic stellate cells functionally contribute to the hepatic innate immune response via TLR3. View >
A reversible model for periportal fibrosis and a refined alternative to bile duct ligation View
IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts. View >
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. View >

2013

Tumor progression locus 2/Cot is required for activation of extracellular regulated kinase in liver injury and toll-like receptor-induced TIMP-1 gene transcription in hepatic stellate cells View >
Inhibition of RelA-Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response. View >
Serotonin paracrine signaling in tissue fibrosis. View >
The c-Rel subunit of NF-κB regulates epidermal homeostasis and promotes skin fibrosis in mice. View >
Pathogenesis of FOLFOX induced sinusoidal obstruction syndrome in a murine chemotherapy model. View >
TNFα from classically activated macrophages accentuates epitheial to mesenchymal transition in obliterative bronchiolitis. View >
Epigenetic regulation of wound healing and fibrosis. View >
An experimemtal study to identify the potential role of pharmacogenomics in determining the occurrence of oxaliplatin-induced liver injury. View >
Epigenetic modifications as new targets for liver disease therapies. View >
The potential contribution of tumour related factors to the development of FOLFOX induced sinusoidal obstruction syndrome. View >

2012

The Histone Methyltransferase ASH1 Orchestrates Fibrogenic Gene Transcription During Myofibroblast Transdifferentiation View >
Multigenerational Epigenetic Adaptation of the Hepatic Wound-Healing Response View >
Cross-talk between DNA methylation and active histone modifications regulates aberrant expression of ZAP70 in CLL. View >
The NF-κB subunit c-Rel stimulates cardiac hypertrophy and fibrosis. View >
Clinical evidence for the regression of liver fibrosis. View >
Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans. View >
Seamless replacement of Autographa californica multiple nucleopolyhedrovirus gp64 with each of five novel Type II Alpha-baculoviral F sequences generates pseudotyped virus that fails to transduce mammalian cells. View >
The critical role of TAK1 in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation. View >
The tumor necrosis factor receptor stalk regions define responsiveness to soluble versus membrane-bound ligand. View >
Transforming growth factor-β1 driven epithelial to mesenchymal transition (EMT) is accentuated by tumor necrosis factor α via crosstalk between the SMAD and NF-κB pathways. View >
Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor γ in hepatic stellate cells for their antifibrotic effect. View >

2011

Stimulating healthy tissue regeneration by targeting the 5-HT(2B) receptor in chronic liver disease. View >
Human T-cell leukemia virus type 1 Tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling. View >
Epigenetic cell fate regulation of hepatic stellate cells. View >

2010

MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis. View >
The NF-κB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple proinflammatory genes. View >
The c-Rel subunit of NF-kB regulates murine liver inflammation, wound-healing and regeneration. View >
The PXR is a drug target for chronic inflammatory disease. View >
A DDX5 S480A polymorphism is associated with increased transcription of fibrogenic genes in hepatic stellate cells. View >
Fibrogenic signalling in hepatic stellate cells. View >
Allele specific regulation of matrix metalloproteinase-3 gene by transcription factor NF-κB. View >
Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF-kB signalling pathways. View >
Role of nuclear factor kappa B in liver health and disease. View >
NF-kappaB signalling: Embracing complexity to achieve translation. View >
Counter-selection recombineering of the baculovirus genome: a strategy for seamless modification of repeat-containing BACs View >
Opposing putative roles for canonical and noncanonical NF-kB signaling on the survival, proliferation, and differentiation potential of human embryonic stem cells. View >

2009

Angiotensin II activates IκB kinase phosphorylation of RelA at Ser536 to promote myofibroblast survival and liver fibrosis. View >
Telmisartan attenuates progression of steatohepatitis in mice: role of hepatic macrophage infiltration and effects on adipose tissue. View >
Active matrix metalloproteinase-2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N-cadherin. View >
Systemic chemotherapy and its implications for resection of colorectal liver metastasis. View >

2008

Hepatic NF-kB regulates neutrophil recruitment to the injured brain. View >
NF-kB is a critical regulator of the survival of rodent and human hepatic myofibroblasts View >
Cellular targeting of the apoptosis-inducing compound gliotoxin to fibrotic livers. View >
The function of serotonin within the liver. View >
Wound healing and local neuroendocrine regulation in the injured liver. View >
Epigenetic regulation of liver fibrosis. View >
A mechanism for the antifibrogenic effects of the pregnane X receptor (PXR) in the liver: Inhibition of NF-B. View >
Fibrosis and cirrhosis reversibility - molecular mechanisms. View >

2007

Nuclear Factor-KappaB and the hepatic inflammation-fibrosis-cancer axis. View >
Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis. View >

Before 2007

(2006). Resolving fibrosis in the diseased liver: translating the scientific promise to the clinic View >
(2006) JunD is a profibrogenic transcription factor regulated by Jun-N-terminal Kinase (JNK)-independent phosphorylation. View >
(2006) Pharmacological inhibitors of NF-kB accelerate apoptosis in chronic lymphocytic leukaemia cells. View >
(2006) A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis. View >
(2006) Pregnane X receptor activators inhibit human hepatic stellate cell transdifferentiation in vitro. View >
(2006) Naltrexone, an opiod receptor antagonist, attenuates liver fibrosis in bile duct ligated rats. View >
(2005) Functional Analysis of HIV Type 1 Nef Reveals a Role for PAK2 as a Regulator of Cell Phenotype and Function in the Murine Dendritic Cell Line View >
(2005) Regulation of hepatic stellate cell apoptosis and recovery from liver fibrosis. View >
(2005) NF-kB: A signal for cancer. View >
(2005) RNA interference mediated in human primary cells via recombinant baculoviral vectors. View >
(2005) Herpesvirus saimiri-based vector biodistribution using non-invasive optical imaging. View >
(2005) Novel sulfasalazine analogues with enhanced NF-B inhibitory and apoptosis promoting activity. View >
(2005) NFkB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury. View >
(2005) Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis. View >
(2004). N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1. View >
(2004) Regulation of tissue inhibitor of metalloproteinase 1 gene transcription by RUNX1 and RUNX2. View >
(2004) MMP-9 gene transcription is induced in myofibroblasts cultured in 3-D collagen I gels: regulation by NF-kB, AP1 and Sp1. View >
(2004) A failure of transforming growth factor-beta1 negative regulation maintains sustained NF-kappaB activation in gut inflammation. View >
(2004) Signal transduction via the NF-B pathway: A targeted treatment modality for infection, inflammation and repair. View >
(2003) Hepatocytes express nerve growth factor during liver injury: Evidence for paracrine regulation of hepatic stellate cell apoptosis. View >
(2003) Basal expression of IkappaBalpha is controlled by the mammalian transcriptional repressor RBP-J (CBF1) and its activator Notch1. View >
(2003) Characterisation of the murine Natural resistance-associated protein 1 promoter: requirements for trans-activation by Miz-1. View >
The NF-kB luciferase mouse: a new tool for real time measurement of NF-kB activation in the whole animal. View >
(2002) c-Myc represses and Miz-1 activates the murine natural resistance-associated protein 1 promoter. View >
(2002) CD40 induces interleukin-6 gene transcription in dendritic cells: regulation by TRAF2, AP-1, NF-kappa B, AND CBF1. View >
(2002) High efficiency gene transfer into cultured primary rat and human hepatic stellate cells using baculovirus vectors. View >
(2001) Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats. View >
(2002) Transcriptional regulation of hepatic stellate cell activation. View >
(2001). JunD regulates transcription of the tissue inhibitor of metalloproteinases-1 and interleukin-6 genes in activated hepatic stellate cells. View >
(2001) Regulation of E-box DNA binding activities during in vivo and in vitro activation of rat and human hepatic stellate cells. View >
(2000) Attenuation and augmentation of ischaemia-related neuronal death by tumour necrosis factor-alpha in vitro. View >
(2000) Chromosomes and Cirrhosis: All's well that ends well. View >
(2000) Upstream TIMP-1 element-1 (UTE-1) is a novel and essential regulatory DNA motif in the human TIMP-1 gene promoter that directly interacts with a 30kDa nuclear protein. View >
(2000) CTL epitopes of HIV-1 Nef: Generation of multiple definitive MHC class I ligands by proteasomes. View >
(1999) Identification of the Nef associated kinase as p21-activated kinase 2. View >
(1999) A macrophage hippocampal slice co-culture system: application to the study of HIV induced brain damage. View >
(1999) Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IkappaB family proteins. View >
(1999) A bi-functional activator/repressor element required for transcriptional activity of the human UCH-L1 gene assembles a neuron-specific protein: single-strand DNA complex. View >
(1999) A soluble factor produced by macrophages mediates the neurotoxic effects of HIV-1 Tat in vitro. View >
(1999) Induction of activator protein 1 (AP-1) in macrophages by human immunodeficiency virus type-1 Nef is a cell type specific response that requires both Hck and MAPK signaling events. View >
(1999) Tissue inhibitors of metalloproteinases: role in liver fibrosis and alcoholic liver disease. View >
(1999) Control of the tissue inhibitor of metalloproteinases-1 (TIMP-1) promoter in culture activated rat hepatic stellate cells: Regulation by AP-1 DNA binding proteins. View >
(1998) The pathogenesis of liver fibrosis: A role for altered matrix degradation. View >
(1998) Tissue inhibitors of metalloproteinases, hepatic stellate cells and liver fibrosis. View >
(1998) A proposed mechanism for the induction of Activator Protein 1 (AP-1) binding by HIV-1 Negative Factor (Nef) in the macrophage cell line RAW267.4. View >
(1997) Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 1. View >
(1997) Protein kinase C-mediated phosphorylation of HIV-1 Nef in human cell lines. View >
(1997) Analysis of the interactions between Nef and cellular proteins. View >
(1997) Regulated expression vectors demonstrate cell-type-specific sensitivity to human immunodeficiency virus type-1 Nef-induced cytostasis. View >
(1996) The human immunodeficiency virus type 1 regulatory protein Tat inhibits interferon-induced iNos activity in a murine macrophage cell line. View >
(1996) Detection of neuron-specific protein gene product (PGP) 9.5 in the rat and zebrafish using anti-human PGP9.5 antibodies. View >
(1996) Identification of evolutionary conserved regulatory sequences in the 5' untranscribed region of the neural-specific ubiquitin C-terminal hydrolase (PGP9.5) gene. View >
(1994) A molecular rheostat. Co-operative rev binding to stem I of the rev-response element modulates human immunodeficiency virus type-1 late gene expression. View >
(1993) HIV regulatory proteins Tat and Rev and their interactions with synthetic RNA. View >
(1992) Recognition of the high affinity binding site in Rev-response element RNA by the human immunodeficinecy virus type-1 Rev protein. View >
(1992) Alternative splicing of the cytoplasmic domain of the neural cell adhesion molecule alters its ability to act as a substrate for neurite outgrowth. View >
(1991) Neurite outgrowth in response to transfected N-CAM and N-cadherin reveals fundamental differences in neuronal responsiveness to CAMs. View >
(1990) Characterisation of the human NCAM gene promoter. View >
(1990) Characterization of a regulatory region within the human neural cell adhesion molecule gene. View >
(1989) Increased intracellular cyclic AMP differentially modulates nerve growth factor induction of three neuronal recognition molecules involved in neurite outgrowth. View >
(1988) Comparison of the effects of NGF, activators of protein kinase C, and a calcium ionophore on the expression of Thy-1 and N-CAM in PC12 cell cultures. View >
(1987) Cholera toxin and dibutyryl cyclic AMP inhibit the expression of neurofilament protein induced by nerve growth factor in cultures of naive and primed PC12 cells. View >
(1987) Cell-cell interactions modulate the responsiveness of PC12 cells to nerve growth factor. View >