Dr. Lee Borthwick

Publications - Dr. Lee Borthwick


  • Fibroblasts Promote Inflammation and Pain via IL-1α Induction of the Monocyte Chemoattractant Chemokine (C-C Motif) Ligand 2. View >
  • Targeting the Bacterial Cytoskeleton of the Burkholderia cepacia Complex for Antimicrobial Development: A Cautionary Tale. View >
  • Reduced telomere length is associated with fibrotic joint disease suggesting that impaired telomere repair contributes to joint fibrosis. View >



  • The role of interleukin-1β as a predictive biomarker and potential therapeutic target during clinical ex vivo lung perfusion. View >
  • Profiling inflammation and tissue injury markers in perfusate and bronchoalveolar lavage fluid during human ex vivo lung perfusion. View >
  • Epigenetic reprogramming in liver fibrosis and cancer. View >
  • Type 2 immunity is protective in metabolic disease but exacerbates NAFLD collaboratively with TGF-β. View >



  •  Role of CD248 as a potential severity marker in idiopathic pulmonary fibrosis View >
  • International consensus on the definition and classification of fibrosis of the knee joint. View >
  • Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine-driven inflammation and fibrosis. View >
  • Liver: Osteopontin and HMGB1: novel regulators of HSC activation. View >
  • Acidic chitinase primes the protective immune response to gastrointestinal nematodes. View >
  • The IL-1 cytokine family and its role in inflammation and fibrosis in the lung. View >
  • Role of Interaction and Nucleoside Diphosphate Kinase B in Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Function by cAMP-Dependent Protein Kinase A. View >
  • Pseudomonas aeruginosa Induced Airway Epithelial Injury Drives Fibroblast Activation: A Mechanism in Chronic Lung Allograft Dysfunction. View >



  • Fibrosis is a common outcome following total knee arthroplasty. View >
  • A potential mode of action for Anakinra in patients with arthrofibrosis following total knee arthroplasty. View >
  • TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma. View >
  • How reliable are sino-nasal cell lines for studying the pathophysiology of chronic rhinosinusitis? View >



  • Incomplete deletion of IL-4Rα by LysM(Cre) reveals distinct subsets of M2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis. View >
  • TNF-α/IL-17 synergy inhibits IL-13 bioactivity via IL-13Rα2 induction. View >
  • Mechanistic differences between phenotypes of chronic lung allograft dysfunction after lung transplantation. View >
  • IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts. View >



  • TNFα from classically activated macrophages accentuates epithelial to mesenchymal transition in obliterative bronchiolitis. View >
  • Role of arginase 1 from myeloid cells in th2-dominated lung inflammation. View >
  • Cytokine mediated tissue fibrosis. View >
  • Inhibition of RelA-Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response View >



  • The critical role of TAK1 in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation. View >
  • Free radical generation induces epithelial-to-mesenchymal transition in lung epithelium via a TGF-β1-dependent mechanism. View >



  • Is CFTR-delF508 really absent from the apical membrane of the airway epithelium? View >
  • Transforming Growth Factor-β1 (TGF-β1) Driven Epithelial to Mesenchymal Transition (EMT) is Accentuated by Tumour Necrosis Factor α (TNFα) via Crosstalk Between the SMAD and NF-κB Pathways. View >



  • Lung epithelial wound healing in health and disease. View >
  • Pseudomonas aeruginosa accentuates epithelial-to-mesenchymal transition in the airway. View >
  • Inflammation and epithelial to mesenchymal transition in lung transplant recipients: role in dysregulated epithelial wound repair. View >



  • Epithelial to mesenchymal transition (EMT) and airway remodelling after human lung transplantation. View >



  • Defective formation of PKA/CnA-dependent annexin 2-S100A10/CFTR complex in DeltaF508 cystic fibrosis cells. View >
  • The annexin 2-S100A10 complex and its association with TRPV6 is regulated by cAMP/PKA/CnA in airway and gut epithelia. View >
  • Airway epithelial cell senescence in the lung allograft. View >
  • CMT3 alters mitochondrial function in murine osteoclast lineage cells View >



  • The formation of the cAMP/protein kinase A-dependent annexin 2-S100A10 complex with cystic fibrosis conductance regulator protein (CFTR) regulates CFTR channel function. View >