Dr. Jack Leslie

Publications - Dr. Jack Leslie

Synthesis and preclinical evaluation of a 89Zr-labelled human single chain antibody for non-invasive detection of hepatic myofibroblasts in acute liver injury View >

Harnessing neutrophil plasticity for HCC immunotherapy View >
The exercise IL-6 enigma in cancer View >
ST3Gal1 synthesis of Siglec ligands mediates anti-tumour immunity in prostate cancer View >
Anti–Cholestatic Therapy with Obeticholic Acid Improves Short-Term Memory in Bile Duct–Ligated Mice View >

Author Correction: Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer View >
Metabolic dysfunction and cancer in HCV: Shared pathways and mutual interactions View >
Neutrophils as potential therapeutic targets in hepatocellular carcinoma View >
Human-correlated genetic HCC models identify combination therapy for precision medicine View >
c-Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis View >
CXCR2 inhibition enables NASH-HCC immunotherapy View >
Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential View >
Sulfatase-2 from Cancer Associated Fibroblasts: An Environmental Target for Hepatocellular Carcinoma? View >

Author Correction: Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis View >
Immunomodulatory effects of lenvatinib plus anti-PD1 in mice and rationale for patient enrichment in hepatocellular carcinoma View >
Author Correction: c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis View >
Non-invasive synchronous monitoring of neutrophil migration using whole body near-infrared fluorescence-based imaging View >
Lipid Remodeling in Hepatocyte Proliferation and Hepatocellular Carcinoma View >
Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner View >
Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression View >
Key features of the environment promoting liver cancer in the absence of cirrhosis View >
P099 Serum gamma glutamyl transferase (γGT) – a prognostic biomarker for detrimental neutrophils in patients with hepatocellular carcinoma (HCC)? View >
Immunomodulatory Effects of Lenvatinib Plus Anti–Programmed Cell Death Protein 1 in Mice and Rationale for Patient Enrichment in Hepatocellular Carcinoma View >
A Mammalian Target of Rapamycin-Perilipin 3 (mTORC1-Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis View >

cRel expression regulates distinct transcriptional and functional profiles driving fibroblast matrix production in systemic sclerosis View >
c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis View >
Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis View >
Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis View >
Loss of ELK1 has differential effects on age-dependent organ fibrosis View >
Ammonia Scavenging Prevents Progression of Fibrosis in Experimental Nonalcoholic Fatty Liver Disease View >
FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis View >

mTORC1-Plin3 pathway is essential to activate lipophagy and protects against hepatosteatosis View >
A Bioreactor Technology for Modeling Fibrosis in Human and Rodent Precision-Cut Liver Slices View >
Enhanced in vivo Optical Imaging of the Inflammatory Response to Acute Liver Injury in C57BL/6 Mice Using a Highly Bright Near-Infrared BODIPY Dye View >
Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer View >

A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A View >

Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease View >
c-Rel and its many roles in cancer: an old story with new twists View >
A new fluorescence-based optical imaging method to non-invasively monitor hepatic myofibroblasts in vivo View >
A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-κB-dependent liver regeneration and cancer. View >

Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease View >