Prof. Fiona Oakley

Publications - Prof. Fiona Oakley

2017

  • A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A. View >
  • The NF-κB1 is a key regulator of acute but not chronic renal injury. View >
  • The new-generation pan-peroxisome proliferator-activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis. View >

 

2016

  • Response to 'Comment on 'The potential contribution of tumour-related factors to the development of FOLFOX-induced sinusoidal obstruction syndrome''. View >
  • A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-κB-dependent liver regeneration and cancer. View >
  • A new fluorescence-based optical imaging method to non-invasively monitor hepatic myofibroblasts in vivo. View >
  • Histone Demethylation and Toll-like Receptor 8-Dependent Cross-Talk in Monocytes Promotes Transdifferentiation of Fibroblasts in Systemic Sclerosis Via Fra-2. View >
  • Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum. View >
  • TPL2 Kinase Is a Crucial Signaling Factor and Mediator of NKT Effector Cytokine Expression in Immune-Mediated Liver Injury. View >
  • Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease. View >

 

2015

  • NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma View >
  • Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease. View >
  • Corrigendum: NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma. View >
  • Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation. View >
  • Transfusion reactions in pediatric compared with adult patients: a look at rate, reaction type, and associated products. View >
  • An expandable donor-free supply of functional hepatocytes for toxicology. View >

 

2014

  • Transfusion reactions in pediatric compared with adult patients: a look at rate, reaction type, and associated products. View >
  • Serum amyloid A induces interleukin-6 in dermal fibroblasts via Toll-like receptor 2, interleukin-1 receptor-associated kinase 4 and nuclear factor-κB. View >
  • Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. View >
  • Noninvasive in vivo magnetic resonance measures of glutathione synthesis in human and rat liver as an oxidative stress biomarker. View >
  • A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. View >
  • Utility of B-13 progenitor-derived hepatocytes in hepatotoxicity and genotoxicity studies. View >
  • Quiescent hepatic stellate cells functionally contribute to the hepatic innate immune response via TLR3. View >

 

2013

  • Tumor progression locus 2/Cot is required for activation of extracellular regulated kinase in liver injury and toll-like receptor-induced TIMP-1 gene transcription in hepatic stellate cells View >
  • Transfusion reactions in pediatric compared with adult patients: a look at rate, reaction type, and associated products. View >
  • A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. View >
  • Utility of B-13 progenitor-derived hepatocytes in hepatotoxicity and genotoxicity studies. View >
  • The potential contribution of tumour-related factors to the development of FOLFOX-induced sinusoidal obstruction syndrome. View >
  • Pathogenesis of FOLFOX induced sinusoidal obstruction syndrome in a murine chemotherapy model. View >
  • Serotonin paracrine signaling in tissue fibrosis. View >
  • The c-Rel subunit of NF-κB regulates epidermal homeostasis and promotes skin fibrosis in mice. View >
  • The impact of tumor size in breast needle biopsy material on final pathologic size and tumor stage: a detailed analysis of 222 consecutive cases. View >
  • Inhibition of RelA-Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response. View >

 

2012

  • The Histone Methyltransferase ASH1 Orchestrates Fibrogenic Gene Transcription During Myofibroblast Transdifferentiation View >
  • Multigenerational Epigenetic Adaptation of the Hepatic Wound-Healing Response View >
  • Serotonin paracrine signaling in tissue fibrosis. View >
  • Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans. View >
  • Roles of c-Rel signalling in inflammation and disease. View >
  • BAG-1 interacts with the p50-p50 homodimeric NF-κB complex: implications for colorectal carcinogenesis. View >
  • The NF-κB subunit c-Rel stimulates cardiac hypertrophy and fibrosis. View >
  • Mechanisms and biomarkers of apoptosis in liver disease and fibrosis. View >

 

2011

  • Stimulating healthy tissue regeneration by targeting the 5-HT(2B) receptor in chronic liver disease. View >
  • Transfusion reactions in pediatric compared with adult patients: a look at rate, reaction type, and associated products. View >
  • BAG-1 interacts with the p50-p50 homodimeric NF-κB complex: implications for colorectal carcinogenesis. View >
  • The NF-κB subunit c-Rel stimulates cardiac hypertrophy and fibrosis. View >

 

2010

  • MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis. View >
  • The NF-κB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple proinflammatory genes. View >
  • The c-Rel subunit of nuclear factor-kappaB regulates murine liver inflammation, wound-healing, and hepatocyte proliferation. View >

 

2009

  • Lipid rafts and caveolin-1 coordinate interleukin-1beta (IL-1beta)-dependent activation of NFkappaB by controlling endocytosis of Nox2 and IL-1beta receptor 1 from the plasma membrane. View >
  • Differences in activities of daily living performance between long-term pediatric sarcoma survivors and a matched comparison group on standardized testing. View >
  • Endosomal Nox2 facilitates redox-dependent induction of NF-kappaB by TNF-alpha. View >
  • Signaling components of redox active endosomes: the redoxosomes. View >
  • Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis. View >

 

2008

  • Multidrug resistance-associated proteins are crucial for the viability of activated rat hepatic stellate cells. View >
  • Ectopic SOX9 mediates extracellular matrix deposition characteristic of organ fibrosis. View >
  • Occupational therapists' role on U.S. Army and U.S. Public Health Service Commissioned Corps Disaster Mental Health Response Teams. View >
  • NF-kappaB is a critical regulator of the survival of rodent and human hepatic myofibroblasts. View >
  • JunD protects the liver from ischemia/reperfusion injury by dampening AP-1 transcriptional activation. View >
  • Hepatic nuclear factor kappa B regulates neutrophil recruitment to the injured brain. View >
  • Nuclear factor-kappaB1: regulation and function. View >

 

2007

  • Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis View >
  • Nuclear factor-kappaB1: regulation and function. View >
  • Cross-cultural reproducibility of the Brazilian Portuguese version of the Role Checklist for persons with chronic obstructive pulmonary disease. View >

 

Before 2007

  • Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis.d View >
  • JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation. View >
  • Naltrexone, an opioid receptor antagonist, attenuates liver fibrosis in bile duct ligated rats. View >
  • A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis. View >
  • The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis. View >
  • Herpesvirus saimiri-based vector biodistribution using noninvasive optical imaging. View >
  • Novel sulfasalazine analogues with enhanced NF-kB inhibitory and apoptosis promoting activity. View >
  • NF-kappaB: a signal for cancer. View >
  • Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury. View >
  • Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis. View >
  • Comparative EST analyses in plant systems. View >