People
Martin Noble
- Professor of Biomolecular Structure & Anticancer Drug Design
Newcastle University Translational and Clinical Research Institute - Email: martin.noble@ncl.ac.uk
- Telephone: +44 (0) 191 208 4466
- Structure-function of protein complexes regulating transcription and the eukaryotic cell cycle.
Kinase inhibitor design and development.
- See a full publication list here.
My group is pursuing structure-function studies of protein complexes involved in regulating transcription and progression through the eukaryotic cell cycle. We are also providing structural biology support to projects within the Drug Discovery and Imaging group of the NICR.
Prior to taking up my appointment in Newcastle I was a Professor at the Laboratory of Molecular Biophysics in the Department of Biochemistry, Oxford University, where I worked from 1993 as postdoc, Royal Society University Research Fellow, University Lecturer, and ultimately Head of Laboratory, after having been recruited initially to the group of Professor Dame Louise Johnson.
My main interest is in understanding the molecular recognition events that drive cellular signalling processes, and in exploiting that understanding to produce new chemical probes and potential leads for drug discovery. This interest has also lead me into the field of bionanotechnology, where protein structures can be recycled as building blocks for novel materials.
Beyond Newcastle, I am chairman of working group 1 and the Executive Committee of Collaborative Computational Project 4, and I sit on the board of Crysalin Ltd., an Oxford University spinout company that is exploiting some of the bionanotechnology IP we have generated.