Newcastle University

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Postdoctoral and research technician positions in understanding how PAR proteins cooperate to establish cell polarity

Start date: Flexible

The laboratory of Dr Josana Rodriguez has a full-time postdoctoral and a part-time (25-50%) research technician position available. The funding is initially available for 3 years. The lab enjoys state of the art equipment and is situated in the ambitious and supportive research environment of the Institute for Cell and Molecular Biosciences, within the Medical School at Newcastle University (Newcastle upon Tyne, UK). We are part of a vibrant scientific community studying cell division from different angles. We are seeking enthusiastic and highly motivated scientists keen to investigate the fundamental principles of cell polarity establishment and asymmetric cell division, both essential to tissue and organ development. We have recently uncovered novel cross-talk regulation/cooperation between key effectors of cell polarity, the PAR proteins. This project will reveal the molecular mechanisms and dynamics underlying this PAR-protein functional cooperation. We will use a multi-disciplinary approach, including proteomics, genetic screens, biochemical assays, genome editing, and cutting edge microscopy (super-resolution). The project will use mainly the nematode C. elegans as a model, but mammalian systems are also available in the lab.

Relevant papers

• Rodriguez J et al. aPKC Cycles between Functionally Distinct PAR Protein Assemblies to Drive Cell Polarity. Dev Cell, 2017 42, 400

• Rodriguez J et al. Systematic genetic interaction screens uncover cell polarity regulators and functional redundancy. Nat Cell Biol, 2013 15, 103

Informal enquiries should be directed to Dr Josana Rodriguez (josana.rodriguez@ncl.ac.uk).