WP4: Real-time monitoring of critical process para

Real-time monitoring of critical process parameters (6-48 months), Research & Training, Lead: LIU

Objectives: To integrate novel real-time sensors and cutting-edge soft sensor models (developed within the WP) with outputs from WP1 - WP3 and thus enabling more effective bioprocess monitoring in the manufacturing environment.

Description: Project 4.A and Project 4.B (host Acreo), Project 4.C and Project 4.D (host LIU) and Project 4.E (UNEW)

Project 4.A: Task 4.1 – Development of electronics for biochips for product detection; Task 4.2 – Testing integrated biochips for product detection with model compounds.

Project 4.B: Task 4.3 –Development of electronics for biochips for media composition measurement; Task 4.4 – Testing integrated biochips for media composition measurement with model compounds.

Project 4.C: Task 4.5 –Bioprocess & electronic sensor data integration for monitoring in bioreactor; Task 4.6 – Testing of the soft sensor in industrial case studies (CHN, FUJI, SAN).

Project 4.D: Task 4.7 –Bioprocess & electronic sensor data integration for process monitoring in DSP; Task 4.8 – Testing of the soft sensor in industrial case studies (CHN, FUJI, SAN).

Project 4.E: Task 4.9 –Overall integration of modelling framework for process development; Task 4.10 – Testing of the framework in industrial case studies (CHN, FUJI, SAN).

Deliverables: D4.1 - Report on appropriate modelling methodologies for soft sensor development for model process of partners (m.18); D4.2 - Report on most appropriate modelling approaches for the general bioprocess monitoring framework (m.18); D4.3 - Two soft sensors adapted to impurity control of chromatography (m.25,42); D4.4 - Two prototypes of an immune/media sensor manufactured (m.26); D4.5 - Immune/media sensors tested in industrial conditions (m.42); D4.6 - Soft sensor system developed & tested in industrial conditions (m.42); D4.7 - Two complete case studies: a manufacturing system for recombinant biopharmaceutical; and a manufacturing system for a drug compound (m.42); D4.8 - Overall framework for rapid screening, process development & monitoring (m.47)