Observational data from clinical systems is frequently complex, involves multiple interactions and encapsulates multifarious behaviours. Modelling clinical outcomes is therefore a significant challenge. It requires a flexible approach and also novel methodologies able to reflect these complexities.
Our work in this area has been diverse and has involved a range of different clinical specialties, although the modelling principles applied have been consistent. Problems addressed have included; factors determining outcomes from hip and knee replacement, assessment of robotic prostatectomy and effective of sexual health services in primary care. Our work on respiratory infections has involved tackling a diverse range of problems necessitating a diverse range of approaches. For example it has included modelling population level spatio-temporal trends in childhood pneumonia as well as modelling individual level risk factors for adverse outcomes following AH1N1v infection and vaccination in pregnancy. This work has required us to build collaborations with a broad range of scientific and clinical organisations including the UK Health Protection Agency, NHS clinicians in obstetrics, paediatrics, respiratory medicine and infectious disease specialties, industry as well as a range of other academic institutions. This work has achieved international recognition.
Current Projects
Cadaveric Modelling of the Appropriate Constrained Implant in Knee Replacement – Development of a Patient-Specific Surgical Tool
Ablative therapy for men with localised prostate cancer
Time trends in UK cases of Scarlet Fever
AH1N1v infection in pregnancy, risk factors and vaccine exposure.
The impact of a conjugate pneumococcal vaccine (Prevenar) on the epidemiology and aetiology of childhood pneumonia in the North East of England
The national programme for enhanced pneumococcal surveillance of complicated pneumococcal pneumonia and empyema in UK children.
An investigation of the UK obesity epidemic: A multi-level systems approach
Current Collaborations
Exploring the link between oral bacteria and hospital acquired pneumonia in hip fracture patients using a novel screening assay
Past Projects
Public health outcomes, costs and cost-effectiveness of GUM and primary care based STI services: How to maximise STI control and cost-effectiveness for a population (MSTIC)
A comparison of laporoscopic and robotic surgery in the treatment of prostate cancer
The Effect of Total Knee Replacement on the Envelope of Laxity of the Knee
Related Papers
- Ghosh KM, Hunt N, Blain A, Athwal KK, Longstaff L, Amis AA, Rushton S, Deehan DJ. Isolated popliteus tendon injury does not lead to abnormal laxity in posterior-stabilised total knee arthroplasty. 2015. DOI: 10.1007/s00167-014-3488-1
- Hunt NC, Ghosh KM, Blain AP, Rushton SP, Longstaff LM, Deehan DJ. No kinematic argument for the use of a posterior-stabilised knee replacement: a cadaveric study on the effects of cruciate-retaining versus posterior-stabilised knee replacement on soft-tissue laxity. 2015. Bone and Joint Journal. In Press.
- Blain AP, Thomas MF, Shirley MDF, Simmister C, Elemraid MA, Gorton R, Pearce MS, Clark JE, Rushton SP, Spencer DA. Spatial variation in the risk of hospitalization with childhood pneumonia and empyema in the North of England. Epidemiology and Infection 2013. http://dx.doi.org/10.1017/S0950268813001015. Published online: 9th May 2013.
- Ghosh M, Blain AP, Longstaff L, Rushton SP, Deehan D. Can we define envelope of laxity during navigated knee arthroplasty? 2013 Knee Surg Sports Traumatol Arthrosc. http://dx.doi.org/10.1007/s00167-013-2574-0.Published online: July 2013.
- Malviya A, Rushton SP, Foster HE, Ferris CM, Hanson H, Muthumayandi K, Deehan DJ. Exploring the relationships between adult juvenile idiopathic arthritis and employment. Arthritis and Rheumatology2012.
- Cloke D, Moore O, Shab T, Rushton S, Shirley MDF, Deehan DJ. Thigh Muscle Injuries in Youth Soccer Predictors of Recovery. American Journal of Sports Medicine 2012, 40(2), 433-439.
- Elemraid MA, Pollard K, Thomas MF, Gennery AR, Eastham KM, Rushton SP, Hampton F, Singleton P, Gorton R, Spencer DA, Clark JE. Validity of using Hospital Episode Statistics data on monitoring disease trends. Thorax 2011;66:827.
- Dadvand P, Rankin J, Rushton S, Pless-Mulloli T. Ambient air pollution and congenital heart disease: A register-based study. Environmental Research 2011, 111(3), 435-441.
- Rushton SP, Shirley MDF, Sheridan EA, Lanyon CV, O'Donnell AG. The transmission of nosocomial pathogens in an intensive care unit: a space-time clustering and structural equation modelling approach. Epidemiology and Infection 2010, 138(6), 915-926.
- Pearce MS, Glinianaia SV, Rankin J, Rushton S, Charlton M, Parker L, Pless-Mulloli T. No association between ambient particulate matter exposure during pregnancy and stillbirth risk in the north of England, 1962-1992. Environmental Research 2010, 110(1), 118-122.
- Yates L, Pierce M, Stephens S, Mill AC, Spark P, Kurinczuk JJ, Valappil M, Brocklehurst P, Thomas SHL, Knight M. Influenza A/H1N1v in pregnancy: an investigation of the characteristics and management of affected women and the relationship to pregnancy outcomes for mother and infant. Health Technology Assessment 2010, 14(34), 109-182.
- Dadvand P, Ruston S, Diggle PJ, Goffe L, Rankin J, Pless-Mulloli T. Using spatio-temporal modelling to predict long-term exposure to black smoke at fine spatial and temporal scale. Atmospheric Environment 2010, 45(3), 659-664.
- Dadvand P, Rankin J, Shirley MDF, Rushton SP, Pless-Mulloli T. Descriptive epidemiology of congenital heart disease in Northern England. Paediatric and Perinatal Epidemiology 2009, 23(1), 58-65.
- Fanshawe TR, Diggle PJ, Rushton SP, Sanderson RA, Lurz PWW, Glinianaia SV, Pearce MS, Parker L, Charlton M, Pless-Mulloli T. Modelling spatio-temporal variation in exposure to particulate matter: a two-stage approach.Environmetrics 2008, 19(6), 549-566.
- McNally RJQ, Rankin J, Shirley MDF, Rushton SP, Pless-Mulloli T. Space-time analysis of Down syndrome: Results consistent with transient pre-disposing contagious agent. International Journal of Epidemiology 2008, 37(5), 1169-1179.
- Rushton SP, Goodfellow M, O'Donnell AG, Magee JG. The epidemiology of atypical mycobacterial diseases in northern England: A space-time clustering and Generalized Linear Modelling approach. Epidemiology and Infection 2007,135(5), 765-774.