For details of the research interests of individual group members, please see People. In brief our expertise lies in the following areas:
Subject areas
- Chromosome segregation in mitosis
- Chromosome biology of oocytes
- Molecular basis of meiotic chromosome synapsis
- Structure and function of cyclin-dependent protein kinases and histone kinases
- Cyclin-dependent kinases in control of the cell cycle and initiation of transcription
- Histone modifications during cell division
- Epigenetic inheritance through cell division
- Mitotic checkpoint signalling
- Cell polarity and asymmetric cell division of embryos
- Telomeres, DNA replication and repair
Technical approaches
- Live and fixed cell fluorescence microscopy
- Cell microinjection
- Cell culture and transfection
- Recombinant protein expression and purification
- Biochemistry and biophysics
- X-ray crystallography
- Structure-aided drug design
- Genetic, yeast two-hybrid, RNAi and small molecule screens
Model systems
- In vitro reconstitution
- Cultured mammalian cells
- Mouse and human oocytes
- C. elegans embryos
- S. cerevisiae (budding yeast)
- Drosophila embryos and neuroblasts