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Haematopoiesis and Immunity Laboratory

The Haematopoiesis and Immunity Lab is based in the Translational and Clinical Research Institute, Newcastle University.  
The immune system develops through the formation of immune cells in the bone marrow, a process known as haematopoiesis.  We study the development of immune cells through haematopoiesis, the genes that control this process and the consequences for immunity when haematopoiesis fails.  We are especially interested in the formation of monocytes, macrophages and dendritic cells and their specialised functions in health and disease.  We have discovered new origins and roles for these cells in bone marrow transplantation, inborn errors of immunity and the histiocytic neoplasms, Langerhans cell histiocytosis and Erdheim Chester disease.

Human DC Deficiency Testing

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Research testing for human dendritic cell (DC) and monocyte immunodeficiencies

Histiocytosis

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More information is available here

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News

23.10.19 Graft versus host disease paper pre-published on bioRxiv

Our most recent publication, defining the origin, functional properties and potential pathogenic roles of human GVHD macrophages, is now available online on bioRxiv! https://www.biorxiv.org/content/10.1101/787036v1.full

Last modified: Wed, 23 Oct 2019 13:51:27 BST

23.09.19 Welcome to Maymoon Madkhali, our new PhD student!

Maymoon's research will focus on improving the outcome of Haematopoietic Stem Cell Transplantation.

Last modified: Wed, 23 Oct 2019 14:18:01 BST

08.04.19 Dendritic cell development publication available on Sneak Peek

Our most recent publication titled "Differential IRF8 Requirement Defines Two Pathways of Dendritic Cell Development in Humans" is now available on Sneak Peek! Read it here: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3365028

Last modified: Mon, 08 Apr 2019 14:48:34 BST

25.03.19 Flt3 paper pre-published on bioRxiv

Our most recent paper describes a simple blood test to monitor response to treatment in acute myeloid leukaemia. Read it here: https://www.biorxiv.org/content/10.1101/588319v1

Last modified: Mon, 08 Apr 2019 14:41:53 BST

15.10.18 Welcome to Jason Lam, our new PhD student!

Jason will be working on mapping the induction of allo-immune effector cells in haematopoietic stem cell transplantation under the supervision of Prof Matt Collin.

Last modified: Wed, 19 Dec 2018 15:39:48 GMT

17.04.18 HuDC lab away day

DC lab away day!

Last modified: Tue, 09 Apr 2019 11:58:26 BST

27.03.18 Ikaros family zinc finger 1 publication

Cytlak et al Ikaros family zinc finger 1 regulates dendritic cell development and function in humans. Read Nature Comms publication here https://www.nature.com/articles/s41467-018-02977-8

Last modified: Fri, 27 Apr 2018 12:37:45 BST

27.02.18 Congratulations to our alumnus Dr Kile Green!

Kile recently completed his PhD with the Human DC lab. His research focused on the transcriptomics of dendritic cell subsets and was funded by Bright Red.

Last modified: Thu, 08 Mar 2018 14:00:32 GMT

03.01.18 Latest update on human dendritic cells in Immunology

Read the article here: https://onlinelibrary.wiley.com/doi/abs/10.1111/imm.12888

Last modified: Fri, 27 Apr 2018 12:31:16 BST

01.09.17 Welcome to Fareeha Tariq, our new PhD student!

Fareeha will be working on the identification of somatic mutations in rheumatoid arhritis, under the supervision of Prof Matt Collin and Dr Amy Anderson. Her project is funded by the British Research Council.

Last modified: Thu, 22 Feb 2018 11:35:21 GMT

01.06.17 Welcome to Dr Preeti Singh, our new research associate!

Preeti's research will be focusing on granulomatous disease and is funded by the Medical Research Council.

Last modified: Thu, 22 Feb 2018 11:52:37 GMT