Below are selected lab publications, or work with collaborators, arranged by area of study.

The role of Lewy bodies in LBD

• Hawksworth JI, Kirkby-Geddes E, Thom S, O'Neill J, Ikwue A, Wood L, Outeiro TF, Erskine D. Lewy Bodies Are Not Associated With Neuronal or Synaptic Loss in Dementia With Lewy Bodies. Neuropathology and Applied Neurobiology 2026, 52, e70085.
• Colloby SJ, McAleese KE, Walker L, Erskine D, Toledo JB, Donaghy PC, McKeith IG, Thomas AJ, Attems J, Taylor JP. Patterns of tau, amyloid and synuclein pathology in ageing, Alzheimer's disease and synucleinopathies. Brain 2025, 148(5), 1562-1576.
• Ghanem SS, Majbour NK, Vaikath NN, Ardah MT, Erskine D, Jensen NM, Fayyad M, Sudhakaran IP, Vasili E, Melachroinou K, Abdi IY, Poggiolini I, Santos P, Dorn A, Carloni P, Vekrellis K, Attems J, McKeith I, Outeiro TF, JEnsen PH, El-Agnaf OMA. α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity. Proceedings of the National Academy of Sciences 2022, 119(15), e2109617119
• Majbour NK, Aasly J, Abdi I, Ghanem S, Erskine D, Van de Berg W, El-Agnaf O. Disease-associated a-synuclein aggregates as biomarkers of Parkinson disease clinical stage. Neurology 2022, Epub ahead of print.
• Koss DJ, Erskine D, Porter A, Palmoski P, Menon H, Todd OGJ, Leite M, Attems J, Outeiro TF. Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies. Acta Neuropathologica Communications 2022, 10, 98.
• Hatton C, Reeve A, Lax NZ, Blain A, Ng YS, El-Agnaf O, Attems J, Taylor JP, Turnbull D, Erskine D. Complex I reductions in the nucleus basalis of Meynert in Lewy body dementia: the role of Lewy bodies. Acta Neuropathologica Communications 2020, (8), 103.

What causes alpha-synuclein aggregation?

• Vasili E, Konig C, Al-Azzani M, Bosbach C, Gaztemeier LM, Thom S, Chegao A, Miranda HV, Steinem C, Erskine D, Outeiro TF. Glycation of alpha-synuclein enhances aggregation and neuroinflammatory responses. npj Parkinson's disease 2025, 11, 307.
• Koss DJ, Todd O, Menon H, Anderson Z, Yang T, Findlay L, Graham B, Palmowski P, Porter A, Morrice N, Walker L, Attems J, Ghanem SS, El-Agnaf O, LeBeau FEN, Erskine D, Outeiro TF. A reciprocal relationship between markers of genomic DNA damage and alpha-synuclein pathology in dementia with Lewy bodies. Molecular Neurodegeneration 2025, 20, 34.
• Hatton C, Ghanem SS, Koss DJ, Abdi IY, Gibbons E, Guerreiro R, Bras J, International DLB Genetics Consortium, Walker L, Gelpi E, Heywood W, Outeiro TF, Attems J, McFarland R, Forsyth R, El-Agnaf OM, Erskine D. Prion-like α-synuclein pathology in the brain of infants with Krabbe disease. Brain 2022, 145(4), 1257-1263.
• Erskine D, Reeve AK, Polvikoski T, Schaefer AM, Taylor RW, Lax NZ, El-Agnaf O, Attems J, Gorman GS, Turnbull DM, Ng YS. Lewy body pathology is more prevalent in older individuals with mitochondrial disease than controls. Acta Neuropathologica 2020, 139, 219-221.

Neurometabolic diseases

• Aisenberg WH, O'Brien CA, Sangster M, Yaqoob F, Zhang Y, Temsamrit B, Thom S, Gosse L, Chaluvadi S, Elfayomi B, Lee G, Polam V, Levitt EM, Liu G, Lombroso SI, Nemec KM, Clowry G, Nieves C, Rawat P, Church E, Martinez D, Shoffler C, Kancheva D, Petucci C, Taylor D, Kofler J, Erskine D, Movahedi K, Bennett ML, Bennett FC. Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease. Immunity 2025, 58(5), 1254-1268.e9.
• Smith LA, Olkhova EA, Lax NZ, Ng YS, Taylor RW, Gorman GS, Erskine D, McFarland R. Delineating the mechanisms of cerebellar degeneration in paediatric and adult primary mitochondrial disease. Acta Neuropathologica 2025, 149(1), 53.
• Kataura T, Sedlackova L, Sun C, Kocak G, Wilson N, Banks P, Hayat F, Trushin S, Trushina E, Maddocks ODK, Oblong JE, Miwa S, Imoto M, Saiki S, Erskine D, Migaud ME, Sarkar S, Korolchuk VI. Targeting the autophagy-NAD axis protects against cell death in Niemann-Pick type C1 disease models. Cell Death and Disease 2024, 15(5), 382.
• Smith LA, Chen C, Lax NZ, Taylor RW, Erskine D, McFarland R. Astrocytic pathology in Alpers’ syndrome. Acta Neuropathologica Communications 2023, 11, 86.
• Ng YS, Lax NZ, Blain AP, Erskine D, Baker MR, Polvikoski T, Thomas RH, Morris CM, Lai M, Whittaker RG, Gebbels A, Winder A, Hall J, Feeney C, Farrugia ME, Hirst C, Roberts M, Lawthom C, Chrysostomou A, Murphy K, Baird T, Maddison P, Duncan C, Poulton J, Nesbitt V, Hanna MG, Pitceathly RDS, Taylor RW, Blakely EL, Schaefer AM, Turnbull DM, McFarland R, Gorman GS. Forecasting stroke-like episodes and outcomes in mitochondrial disease. Brain 2022, 145(2), 542-554.
• Smith LA, Erskine D, Blain A, Taylor RW, McFarland R, Lax NZ. Delineating selective vulnerability of inhibitory interneurons Alpers' syndrome. Neuropathology and Applied Neurobiology 2022, 48(6), e12833.