CONFORM-OH is a new trial examining the effectiveness of different treatment strategies for patients with orthostatic hypotension (OH). 

People with OH experience abnormal drops in their blood pressure when they stand up after sitting or lying down. This can cause a variety of symptoms, most commonly dizziness, but can also cause falls and faints. The study is comparing the effectiveness of non-drug treatments with the tablets fludrocortisone and midodrine, all of which are used routinely in the NHS.

Despite OH being a common condition, there has been very little research on which treatment is most effective at improving the symptoms of OH.

The study is funded by the National Institute for Health Research (NIHR) Health Technology Assessment Programme and led by Doctor James Frith from Newcastle University and Newcastle upon Tyne NHS Foundation Trust.

Trial Design

A pragmatic, open label, randomised, prospective, superiority, multi-arm, multi-stage clinical trial with a 10-month internal pilot

Participants

Adults with symptomatic orthostatic hypotension receiving treatment in secondary care

Planned Size

366 (122 per treatment arm)

Treatment Duration

12 Months

To find out more about the study and what it might mean for someone to take part, you can access the patient information leaflet for the study here: