Previous Seminars
ICaMB Seminar - Prof Tom Owen-Hughes
- Venue: Baddiley Clark Seminar Room
- Start: Wed, 08 May 2019 13:00:00 BST
- End: Wed, 08 May 2019 14:00:00 BST
Remodelling chromatin from yeast to cancer
The genomes of eukaryotes associate with histone proteins to form chromatin. Chromatin is the substrate for all genetic processes and as a result of fundamental importance to a diverse range of biological processes including development and disease. Indeed chromatin is currently of significant interest both in the development of biomarkers for diseases and as a source of new therapeutic targets. Eukaryotes use a range of strategies to alter chromatin structure. These include the use of histone modifications, histone chaperones and ATP dependent remodelling enzymes. The Owen-Hughes lab is generally interested in how these different strategies are coordinated to ensure appropriate gene regulation.
Title: Chromatin remodelling and cancer