Previous Seminars
ICaMB Seminar - Prof Jonathon Pines
- Venue: Baddiley-Clark Seminar Room
- Start: Wed, 09 Apr 2014 13:00:00 BST
- End: Wed, 09 Apr 2014 14:00:00 BST
Prof Jonathon Pines, University of Cambridge, is presenting the next ICaMB seminar with a talk entitled:
“Understanding how cells prevent aneuploidy: towards a quantitative analysis of the spindle assembly checkpoint”
Jonathon Pines has been at the forefront of cell cycle research ever since cloning sea urchin cyclin in Tim Hunt’s lab in 1987 (Pines and Hunt, EMBO J 1987). He is now Director of Research in Cell Division for Cancer Research UK, and his lab at the Gurdon Institute in Cambridge has published a dazzling array of seminal papers on the mitotic cell cycle. He was a pioneer in using GFP tagging to elegantly demonstrate Cyclin B localisation and destruction in live cells (Clute and Pines, Nat. Cell Biol. 1999), a technique which has since had immense impact in cell biology labs around the world. He then went on to dissect how cell cycle proteins are destroyed in an orderly and timely manner, the significance of which is crucial to normal cell cycle progression and prevention of aneuploidy with its catastrophic consequences (Pines, Trends Cell Biol 2006). His most recent paper shows that the critical regulator of mitosis, the spindle assembly checkpoint, is not regulated in a simple ‘on/off’ manner, but is instead exquisitely sensitive to cellular levels and localisation of one of its component proteins (Collin et al, Nat Cell Biol. 2013).
Jonathon is an excellent speaker and his lab is involved in fascinating work of relevance both scientifically and clinically. Please come and listen to what promises to be an excellent talk