Previous Seminars
NICR Seminar - Steve Smerdon
- Venue: Paul O'Gorman Building Seminar Room
- Start: Mon, 31 Mar 2014 13:00:00 BST
- End: Mon, 31 Mar 2014 14:00:00 BST
Prof Smerdon's studies have revealed the structures of 14-3-3, Forkhead-associated, Brca1-C-terminus and Polo-box domain complexes and have found a remarkable diversity in binding modes. These observations have led to an additional interest in the regulation of several kinases that play crucial roles in the DNA damage response and its integration into the cell cycle. By understanding the molecular basis of specificity within such an extensive web of regulatory interactions, his lab aims to determine why these processes run amok, and how drugs might be designed to combat the devastating effects associated with cancer and other diseases.