Previous Seminars
ICaMB Seminar - JP Arulanandam
- Venue: Baddiley Clark Seminar Room
- Start: Wed, 13 Mar 2019 13:00:00 GMT
- End: Wed, 13 Mar 2019 14:00:00 GMT
Title: Towards the Structural Basis for Centromere Maintenance
Jeyaprakash is a Wellcome Senior Research Fellow at the Wellcome Centre for Cell Biology (WCCB), University of Edinburgh, UK. JP, as he is known among his colleagues and peers, completed his PhD in 2004 at the Indian Institute of Science, Bangalore with Prof. M. Vijayan. He obtained Alexander von Humboldt and Marie-Curie Fellowships to work with Elena Conti at EMBL-Heidelberg and subsequently at the Max-Planck Institute of Biochemistry, Martinsried, Germany. After a successful postdoctoral research JP received a Wellcome Career Development fellowship to start his independent research group at the WCCB in 2012. Since 2017, he is a Wellcome Senior Research Fellow. JP’s lab is interested in understanding structural level mechanistic details of processes regulating centromere inheritance and chromosome segregation. His major contributions thus far include the structural characterization of the Chromosomal Passenger Complex and the Ska complex, key protein assemblies involved in the physical attachment of chromosomes to spindle microtubule during cell division.
During the talk JP will discuss some of his lab's recent efforts to obtain molecular insights into: 1. the intermolecular protein interactions responsible for the maintenance of centromeres, defined by the enrichment of a histone H3 variant CENP-A and 2. the mechanisms controlling the chromosome association of the Chromosomal Passenger Complex critical for faithful chromosome segregation