Previous Seminars
ICaMB Seminar - Dr Ulrike Gruneberg
- Venue: Baddiley Clark Seminar Room
- Start: Wed, 29 Nov 2017 13:00:00 GMT
- End: Wed, 29 Nov 2017 14:00:00 GMT
Regulation of mammalian chromosome segragation by mitotic phosphatases: licensing the spindle assembly checkpoint
Research in the Gruneberg laboratory focuses on understanding how equal chromosome segregation is achieved during mammalian cell division. Faithful genome segregation requires the attachment of the paired sister chromatids making up each chromosome to spindle microtubules from opposite poles of the mitotic spindle. The correct attachment of the chromosomes to the microtubules via kinetochores is critical for successful chromosome segregation and is monitored by a cellular surveillance system referred to as the “spindle assembly checkpoint” (SAC).
Ulrike is interested in understanding the different processes that contribute to the fidelity of chromosome segregation. The lab aims to address key questions. How is the formation of the mitotic spindle regulated? How do the chromosomes attach to the microtubules? How does the SAC work?
To study these processes they use mammalian tissue culture cells and employ a combination of biochemical and cell biological methods including imaging of both live and fixed cells, and mass spectrometry and in vitro kinase and phosphatase assays.
https://www.path.ox.ac.uk/content/ulrike-gruneberg