Previous Seminars
ICaMB Seminar - Alessandro Costa
- Venue: Baddiley Clark Seminar Room
- Start: Wed, 24 Apr 2019 13:00:00 BST
- End: Wed, 24 Apr 2019 14:00:00 BST
A hallmark of cancer cells is genomic instability, arising from errors in the mechanisms that maintain gene copy number and chromosome ploidy.
Alessandro Costa's research aims to understand how macromolecular machines involved in DNA replication function to preserve chromosome integrity.
To address these issues, they employ a combination of single-particle cryo-electron microscopy and biochemistry, to generate mechanistic models that explain the basis of key nucleic acid transactions. For example, they are interested in understanding how replicative helicases collaborate with the polymerases to couple DNA unwinding with DNA synthesis.
By describing the architecture and dynamics of the DNA replication/recombination machinery, they seek to establish a molecular framework that explains how higher eukaryotes respond to DNA damage and how cell proliferation is regulated to avoid tumorigenesis.
Tilte: Mechanism of eukaryotic DNA replication studied by cryo-electron microscopy