Previous Seminars
ICaMB Extra Seminar - Prof Jessica Downs
- Venue: Baddiley-Clark Seminar Room
- Start: Wed, 15 May 2019 13:00:00 BST
- End: Wed, 15 May 2019 14:00:00 BST
Jessica Downs is the Professor of Epigenetics and Genome Stability at The Institute of Cancer Research in London. She did her PhD at the Gurdon Institute at Cambridge University followed by a postdoctoral position studying DNA repair. In 2002, Jessica was awarded the Jenner Fellowship from the Lister Institute of Preventive Medicine, which she used to establish her own lab in the Biochemistry Department at Cambridge University, followed by a move to the Genome Damage and Stability Centre at Sussex. In 2016, Jessica relocated the lab to the Institute of Cancer Research to join the Division of Cancer Biology. Research in the Downs lab is aimed at understanding the impact of chromatin structure and epigenetic regulation on DNA damage responses and the maintenance of genome stability.
Selected recent publications:
Benstead-Hume, G., et al. (2019). Predicting synthetic lethal interactions using conserved patterns in protein interaction networks. Plos comput biol, Vol.15 (4), p. e1006888.
Meisenberg, C., et al., (2019). Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability. Mol cell, Vol.73(2), pp. 212-223.e7.
Jeggo, P.A., Downs, J.A. & Gasser, S.M. (2017). Chromatin modifiers and remodellers in DNA repair and signalling. Philos trans r soc lond b biol sci, Vol.372 (1731).
Kakarougkas, A., et al., (2014). Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin. Mol cell, Vol.55 (5), pp. 723-732.
Brownlee, P.M., et al., (2014). BAF180 promotes cohesion and prevents genome instability and aneuploidy. Cell rep, Vol.6 (6), pp. 973-981.