Previous Seminars
Additional ICaMB Seminar: Dr Imrich Barak
- Venue: Baddiley-Clark Seminar Room
- Start: Thu, 03 Dec 2015 13:00:00 GMT
- End: Thu, 03 Dec 2015 14:00:00 GMT
Dr. Imrich Barak, Head of Department of Molecular Biology, Institute of Molecular Biology, Slovak Academy of Sciences, Bratislava, will describe "Asymmetric cell division during sporulation in Bacillus subtilis"
Bacillus subtilis is a Grampositive microorganism which is able to differentiate during process called sporulation. The first clear morphological manifestation of sporulation is the formation of an asymmetric septum which partitions the cell into two compartments, the mother cell and forespore. The main aim of the talk will be about the process of initiation and assembly of asymmetric sporulation septum on the molecular level with emphasis on the role of SpoIIE. Although this protein has a critical function in determining the site of formation of the sporulation septum, it is not understood (i) how it localises to the polar septum (ii) how it causes FtsZ to relocalise from mid-cell to the polar site (iii) what role SpoIIE plays in septal thinning or (iv) how its SpoIIAA~P phosphatase activity is controlled so that sigF acitivation is delayed until the septum is completed (v) what role SpoIIE playes in SpoIIQ-SpoIIIAH channel formation. In addition, this lecture will discuss the new method of "slimfield" microscopy employed in this research.