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Paper on new mitotic histone modification published
A collaboration with Markus Seibert and others in Lino Schmitz's lab at Justus-Liebig-University, Giessen, reveals new mitotic phosphorylation site and the kinases responsible.
The work identifies a new phosphorylation event on histone H2B at serine 6 during mitosis. CDK1 and PP1 act as writers and erasers of this modification, with Aurora B also contributing, most likely by inhibiting PP1. This phosphorylation contributes to chromatin dislocation of the histone chaperone SET during mitosis and is required for mitotic chromosome segregation. Nik Watson and Onur Sen in Jon Higgins' lab made significant contributions to the work.
Last modified: Mon, 25 Feb 2019 10:41:11 GMT