Mengchun Li

• CDT Doctoral Researcher Supervisor: Prof Matthias Trost
• Email: m.li98@newcastle.ac.uk
• Project Title: Mass spectrometry approaches to address capability gaps in drug discovery for membrane transporters

Institution: Newcastle University

Project Summary: Membrane transporters regulate solute concentration across biological membranes, vital for homeostasis of cytoplasm and intracellular organelles. Recently, with the increasing statistical power of variant-to-phenotype association, multiple transporters have shown remarkable and unexpected association to human disease, suggesting this family holds significant promise for the development of novel therapeutics. This project will develop both the cell-based functional assays and binding assays using advanced mass spectrometry to address the two significant capability gaps for membrane transporters/proteins drug discovery.

Interesting Fact: The first song I played on the bass is Maneskin's Mammamia.