Josh Rawlinson

• CDT Doctoral Researcher Supervisor: Prof. AnnMarie O’Donoghue
• Email: joshua.d.rawlinson@durham.ac.uk
• Project Title: Delivering Mechanistic Understanding and Novel Approaches to Native Chemical Ligation

Institution: Durham University

Project Summary: Native chemical ligation allows us to synthesis proteins from unprotected peptide fragments under mild conditions. The aim of my project is to answer the key mechanistic questions behind the native chemical ligation reaction that have remained unanswered for almost 30 years. Using the knowledge gained from these studies we will then explore novel approaches to native chemical ligation.