Structural requirements for the specific binding of CRABP2 to cyclin D3. Martyna W. Pastok, Charles W E Tomlinson, Shannon Tuberville, Abbey M Butler, Arnaud Basle, Martin E M Noble, Jane A Endicott, Ehmke Pohl, Natalie J Tatum. https://www.sciencedirect.com/science/article/pii/S0969212624004623?via%3Dihub

S-Aryl Substitution Enhances Acidity of the 1,2,4-Triazolium Scaffold. Matthew S. Smith, Toby J. Blundell, Ian Hickson, AnnMarie C. O’Donoghue. https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.202400753

Metal Binding Amino Acids. Katherine Deck and William D. G. Brittain. http://dx.doi.org/10.1039/D4OB01326C

Evaluation of the Leishmania Inositol Phosphorylceramide Synthase as a Drug Target Using a Chemical and Genetic Approach. Edubiel A. Alpizar-Sosa, Flavia M. Zimbres, Brian S. Mantilla, Emily A. Dickie, Wenbin Wei, Gabriela A. Burle-Caldas, Laura N. S. Filipe, Katrien Van Bocxlaer, Helen P. Price, Ana V. Ibarra-Meneses, Francis Beaudry, Christopher Fernandez-Prada, Philip D. Whitfield, Michael P. Barrett, Paul W. Denny. https://pubs.acs.org/doi/10.1021/acsinfecdis.4c00284 

A Stereodivergent Multicomponent Approach for the Synthesis of C–N Atropisomeric Peptide Analogues. Natalie J. Roper, Aaron D. G. Campbell, Paul G Waddell, Alistair K. Brown, Kristaps Ermanis, Roly J. Armstrong. https://pubs.rsc.org/en/content/articlelanding/2024/sc/d4sc04700a 

Inducible auto-phosphorylation regulates a widespread family of nucleotidyltransferase toxins. Tom J. Arrowsmith, Xibling Xu, Shangze Xu, Ben Usher, Peter Stokes, Megan Guest, Agnieszka K. Bronowska, Pierre Genevaux, Tim R. Blower. https://www.nature.com/articles/s41467-024-51934-1

Structure and rational engineering of the PglX methyltransferase and specificity factor for BREX phage defence. Sam C. Went, David M. Picton, Richard D. Morgan, Andrew Nelson, Aisling Brady, Giuseppina Mariano, David T. F. Dryden, Darren L. Smith, Nicolas Wenner, Jay C. D. Hinton, Tim R. Blower. https://www.nature.com/articles/s41467-024-51629-7  

Phage anti-CRISPR control by an RNA- and DNA-binding helix–turn–helix protein. Nils Birkholz, Kotaro Kamata, Maximilian Feussner, Max E. Wilkinson, Christian Cuba Samaniego, Angela Migur, Dari Kimanius, Marjin Ceelen, Sam C. Went, Ben Usher, Tim R. Blower, Chris M. Brown, Chasse L. Beisel, Zasha Weinberg, Robert D. Fagerlund, Simon A. Jackson, Peter C. Fineran. https://www.nature.com/articles/s41586-024-07644-1#Ack1  

Synthesis, Structure and Stereodynamics of Atropisomeric N-Chloroamides. Aaron D. G. Campbell, Natalie J. Roper, Paul G Waddell, Corinne Wills, Casey Dixon, Ross Matthew Denton, Kristaps Ermanis, Roly J Armstrong. https://pubs.rsc.org/en/content/articlelanding/2024/cc/d4cc00268g 

Riemannian geometry and molecular similarity I: spectrum of the Laplacian. Stuart J. Hall, Rachael Pirie, Daniel J. Cole. https://royalsocietypublishing.org/doi/10.1098/rspa.2023.0343#d1e12007 

No evidence for competition over floral resources between winter-active parasitoids and pollinators in agroecosystems. Lucy Alford, Sacha Roudine, Dimitra Valsami, Tiphanie Fontaine-Guenel, Talay Namintraporn, AnaëlleGuedon, Romane Normand, Ludovic Lagneau, Cecile Le Lann, Joan Van Baaren. https://www.nature.com/articles/s41598-024-52146-9  

Micelle-Promoted Reductive Amination of DNA-Conjugated Amines for DNA-Encoded Library Synthesis. Matthew Anderson, Thomas Carton, Catherine Salvini, James Crawford, Garry Pairaudeau, Mike J. Waring. https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202400239 

Toxin release by conditional remodelling of ParDE1 from Mycobacterium tuberculosis leads to gyrase inhibition. Izaak N Beck, Tom J Arrowsmith, Matthew J Grobbelaar, Elizabeth H C Bromley, Jon Marles-Wright, Tim R Blower. https://academic.oup.com/nar/article/52/4/1909/7479384  

Writhing from Biophysics to Solar Physics and Back. Christopher Prior, Arron N. Bale. https://agupubs.onlinelibrary.wiley.com/doi/10.1002/9781119841715.ch9 

Identification and engineering of potent cyclic peptides with selective or promiscuous binding through biochemical profiling and bioinformatic data analysis. Thomas P. Smith, Bhaskar Bhushan, Daniele Granata, Christian S. Kaas, Birgitte Andersen, Klass W. Decoene, Qiansheng Ren, Haimo Liu, Xinping Qu, Yang Yang, Jia Pan, Quijia Chen, Martin Münzel, Akane Kawamura. https://pubs.rsc.org/en/content/articlelanding/2024/cb/d3cb00168g 

Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function. Oliver D. Coleman, Jessica Macdonald, Ben Thomson, Jennifer A. Ward, Christopher J. Stubbs, Tom E. McAllister, Shane Clark, Siddique Amin, Yimang Cao, Martine I. Abboud, Yijia Zhang, Hitesh Sanganee, Kilian V. M. Huber, Tim D. W. Claridge, Akane Kawamura. https://pubs.rsc.org/en/content/articlelanding/2023/sc/d2sc05944d  

Development of a Micella-Promoted Heck Reaction for the Synthesis of DNA-Encoded Libraries. Harriet A. Stanway-Gordon, Jake A. Odger, Mike J. Waring. https://pubs.acs.org/doi/10.1021/acs.bioconjchem.3c00051 

The SKMT Algorithm: A method for assessing and comparing underlying protein entanglement. Arron Bale, Robert Rambo, Christopher Prior. https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011248 

Micelle-Mediated Sonogashira Coupling for DNA-Encoded Library Synthesis. Jessica S. Graham, Harriet A. Stanway-Gordon, Mike J. Waring. https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202300603  

Cysteine synthase: multiple structures of a key enzyme in cysteine synthesis and a potential drug target for Chagas disease and leishmaniasis. Kate Sowerby, Stefanie Freitag-Pohl, Ana Milena Murillo, Ariel Mariano Silber, Ehmke Pohl. https://journals.iucr.org/d/issues/2023/06/00/di5064/index.html 

A beginner’s guide to current synthetic linker strategies towards VHL-recruiting PROTACs. Nikol A. Zografou-Barredo, Alex J. Hallatt, Jennyfer Goujon-Ricci, Céline Cano. https://www.sciencedirect.com/science/article/pii/S0968089623001827  

Going Full Circle with Organocatalysis and Biocatalysis: The Latent Potential of Cofactor Mimics in Asymmetric Synthesis. Jacob Murray, David R. W. Hodgson, AnnMarie C. O’Donoghue. https://pubs.acs.org/doi/10.1021/acs.joc.2c02747  

Toxi-antitoxin systems as mediators of phage defence and the implications for abortive infection. Abigail Kelly, Tom J Arrowsmith, Sam C Went, Tim R Blower. https://www.sciencedirect.com/science/article/pii/S1369527423000309?via%3Dihub  

Fragment expansion with NUDELs-poised DNA-encoded libraries. Catherine Salvini, Benoit Darlot, Jack Davison, Mathew Martin, Susan Tudhope, Shannon Tuberville, Akane Kawamura, Martin Noble, Steve Wedge, James Crawford, Michael Waring. https://pubs.rsc.org/en/content/articlelanding/2023/sc/d3sc01171b

Nitration of chemokine CXCL8 acts a natural mechanism to limit acute inflammation. Sarah Thompson, Chong Yun Pang, Krishna Mohan Sepuru, Seppe Cambier, Thomas P. Hellyer, Jonathan Scott, A. John Simpson, PualProsst, John A. Kirby, Krishna Rajarathnam, Neil S. Sheerin, Simi Ali. https://link.springer.com/article/10.1007/s00018-022-04663-x

A high-throughput MALDI-TOF MS biochemical screen for small molecule inhibitors of the antigen aminopeptidase ERAP1. Leonie Müller, Amy K Burton, Chloe L Tayler, James E Rowedder, Jonathan P Hutchinson, Simon Peace, Julie M Quayle, Melanie V Leveridge, Roland S Annan, Matthias Trost, Rachel E Peltier-Heap, Maria Emilia Dueñas. https://www.sciencedirect.com/science/article/pii/S247255522213707X?via%3Dihub 

An open-sourcemolecular builder and free energy preparation workflow. Mateusz K. Bieniek, Ben Cree, Rachael Pirie, Joshue T. Horton, Natalie J. Tatum, Daniel J. Cole. https://www.nature.com/articles/s42004-022-00754-9  

Synthesis and In Vivo Evaluation of a Site-Specifically Labelled Radioimmunoconjugate for Dual-Modal (PET/NIRF) Imaging of MT1-MMP in Sarcomas. Toni A. Pringle, Corey D. Chan, Saimir Luli, Helen Blair, Kenneth S. Rankin, James C. Knight. https://pubs.acs.org/doi/10.1021/acs.bioconjchem.2c00306  

In situ excitation of BODIPY fluorophores by 89Zr-generated Cerenkov luminescence. Katie Gristwood, Saimir Luli, Kenneth S. Rankin, James C. Knight. https://pubs.rsc.org/en/content/articlelanding/2022/cc/d2cc03875g  

The Influence of Degree of Labelling upon Cellular Internalisation of Antibody-Cell Penetrating Peptide Conjugates. Toni A. Pringle, Oliver Coleman, Akane Kawamura, James C. Knight.https://pubs.rsc.org/en/content/articlelanding/2022/ra/d2ra05274a  

Scope of on-DNA nucleophilic aromatic substitution on weakly-activated heterocyclic substrates for the synthesis of DNA-encoded libraries. Isaline F.S.F Castan, Andrew Madin, Garry Pairaudeau and Michael J Waring. https://doi.org/10.1016/j.bmc.2022.116688 

A widespread family of WYL-domain transcriptional regulators co-localizes with diverse phage defence systems and islands. David M Picton, Joshua D Harling-Lee, Samuel J Duffner, Sam C Went, Richard D Morgan, Jay C D Hinton, Tim R Blower. https://academic.oup.com/nar/article/50/9/5191/6584439?login=true  

Structure and assembly of the S-layer in C. difficile. Paola Lanzoni-Mangutchi, Oishik Banerji, Jason Wilson, Anna Barwinska-Sendra, Joseph A. Kirk, Filipa Vaz, Shauna O’Beirne, Arnaud Baslé, Kamel El Omari, Armin Wagner, Neil F. Fairweather, Gillian R. Douce, Per A. Bullough, Robert P. Fagan and Paula S. Salgado. https://www.nature.com/articles/s41467-022-28196-w

Design considerations of benchtop fluid flow bioreactors for bio-engineered tissue equivalents in vitro. H. W. Hoyle, C. M. L. Stenger, S. A. Przyborski https://www.sciencedirect.com/science/article/pii/S2666534422000253?via%3Dihub 

Micellar Buchwald-Hartwig Coupling of Aryl and Heteroarylamines for the Synthesis of DNA-Encoded Libraries. Jessica S. Graham, James H. Hunter, and Michael J. Waring. https://pubs.acs.org/doi/10.1021/acs.joc.1c02325  

On-DNA Transfer Hydrongenolysis and Hydrogenation for the Synthesis of DNA Encoded Chemical Libraries. Harriet. A. Stanway-Gordon, Jessica S. Graham and Michael J. Waring. https://doi.org/10.1002/anie.202111927  

Triazolium Salt Organocatalysis: Mechanistic Evaluation of Unusual Ortho-Substituent Effects on Deprotonation. Peter Quinn, Matthew S. Smith, Jiayun Zhu, David R. W. Hodgson and AnnMarie C. O’Donoghue. https://doi.org/10.3390/catal11091055  

On the design of lead-like DNA-encoded chemical libraries. Isaline F.S.F. Castan, Jessica S. Graham, Catherine L.A. Salvini, Harriet A. Stanway-Gordon, Michael J. Waring. https://doi.org/10.1016/j.bmc.2021.116273  

Highly efficient on-DNA amide couplings promoted by micelle forming surfactants for the synthesis of DNA encoded libraries. James H. Hunter, Matthew J. Anderson, Isaline F. S. F. Castan, Jessica S. Graham, Catherine L. A. Salvini, Harriet A. Stanway-Gordon, James J. Crawford, Andrew Madin,  GarryPairaudeauand  Michael J. Waring. https://pubs.rsc.org/en/content/articlelanding/2021/sc/d1sc03007h

Kinetic and structure–activity studies of the triazolium ion-catalysed benzoin condensation. Richard S. Massey, Jacob Murray, Christopher J. Collett, Jiayun Zhu, Andrew D. Smith and AnnMarie C. O’Donoghue. https://doi.org/10.1039/D0OB02207A  

Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications. Carissa M. Lloyd, Neil Colgin and Steven L. Cobb. https://doi.org/10.3390/molecules25235601  

Synthesis of complex unnatural fluorine-containing amino acids. William D.G. Brittain, Carissa M. Lloyd, Steven L. Cobb. https://doi.org/10.1016/j.jfluchem.2020.109630  

Unusually high a-proton acidity of prolyl residues in cyclic peptides. Oliver R. Maguire, Bethany Taylor, Eleanor M. Higgins, Matthew Rees, Steven L. Cobb, Nigel S. Simpkins, Christopher J. Hayes and AnnMarie C. O'Donoghue. https://doi.org/10.1039/D0SC02508A  

A machine learning based intramolecular potential for a flexible organic molecule. Cole DJ, Mones L, Csányi G. https://doi.org/10.1039/D0FD00028K  

89Zr-PET imaging of DNA double-strand breaks for the early monitoring of response following α- and β-particle radioimmunotherapy in a mouse model of pancreatic ductal adenocarcinoma. Poty S, Mandleywala K, O'Neill E, Knight JC, Cornelissen B, Lewis JS. https://doi.org/10.7150/thno.44772  

N-Terminal speciation for native chemical ligation. Oliver R. Maguire, Jiayun Zhu, William D. G. Brittain, Alexander S. Hudson, Steven L. Cobb and AnnMarie C. O’Donoghue. https://doi.org/10.1039/D0CC01604G  

Applications of novel bioreactor technology to enhance the viability and function of cultured cells and tissues. H. W. Hoyle, L. A. Smith, R. J. Williams and S. A. Przyborski. https://doi.org/10.1098/rsfs.2019.0090