Events
MoSMed Research Seminar: Prof Kelly Chibale (University of Cape Town)
- Venue: Bedson Building, Lecture Theatre 2.76
- Start: Wed, 13 May 2026 15:00:25 BST
- End: Wed, 13 May 2026 16:30:46 BST
Title: Mycobacterium tuberculosis-mediated drug metabolism in small molecule drug discovery & development
Abstract: In small molecule drug discovery and development, drugs are normally optimized for hepatic metabolism. However, in tuberculosis (TB) drug discovery, drug metabolism mediated by the causative agent, Mycobacterium tuberculosis (Mtb), needs to be factored in. Mtb-mediated drug metabolism has potential implications both on the efficacy of TB drugs but also on the efficacy of co-administered drugs in patients with co-morbidities. To ensure optimal drug dosages, this warrants the consideration of both hepatic and Mtb-mediated drug metabolism when optimizing small molecule drug candidates as well as in treating patients with co-morbidities.
This lecture will describe completed and ongoing work on Mtb-mediated drug metabolism and model-informed approaches to optimizing pharmacotherapy in patients with co-morbidities.
For more information about Kelly's research, please see here: https://kellychibaleresearch.uct.ac.za/
