2020

A Real-World Observational Cohort of Patients with Hepatocellular Carcinoma: Design and Rationale for TARGET-HCC

Hepatology Communications. doi: 10.1002/hep4.1652

 

Effect of ramucirumab on ALBI grade in patients with advanced HCC: Results from REACH and REACH-2

JHEP Reports. doi: 10.1016/j.jhepr.2020.100215

 

ISG15 protects human Tregs from interferon alpha-induced contraction in a cell-intrinsic fashion

Clinical & Translational Immunology. doi: 10.1002/cti2.1221

 

The immune system view of the coronavirus SARS-CoV-2

Biology Direct. doi: 10.1186/s13062-020-00283-2

 

Cellular and gene signatures of tumor-infiltrating dendritic cells and natural-killer cells predict prognosis of neuroblastoma

Nature Communications. doi: 10.1038/s41467-020-19781-y

 

c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis

Nature Metabolism. doi: 10.1038/s42255-020-00306-2

 

 

CRISPR-Mediated Base Conversion Allows Discriminatory Depletion of Endogenous T Cell Receptors for Enhanced Synthetic Immunity

Molecular Therapy: Methods & Clinical Development. doi: 10.1016/j.omtm.2020.09.002

 

Breath Biopsy Assessment of Liver Disease Using an Exogenous Volatile Organic Compound-Toward Improved Detection of Liver Impairment

Gastroenterology. doi: 10.14309/ctg.0000000000000239

 

The Role of Sinusoidal Endothelial Cells in the Axis of Inflammation and Cancer Within the Liver

Frontiers in Physiology. doi: 10.3389/fphys.2020.00990

 

Cellular senescence as a potential mediator of COVID-19 severity in the elderly

Aging Cell. doi: 10.1111/acel.13237

 

Copy-Number Alteration Burden Differentially Impacts Immune Profiles and Molecular Features of Hepatocellular Carcinoma

Clinical Cancer Research. doi: 10.1158/1078-0432.CCR-20-1497

 

Second-line cabozantinib after sorafenib treatment for advanced hepatocellular carcinoma: a subgroup analysis of the phase 3 CELESTIAL trial

ESMO Open. doi: 10.1136/esmoopen-2020-000714

 

Ramucirumab in the second-line for patients with hepatocellular carcinoma and elevated alpha-fetoprotein: patient-reported outcomes across two randomised clinical trials

ESMO Open. doi: 10.1136/esmoopen-2020-000797

 

Phase Ib Study of Lenvatinib Plus Pembrolizumab in Patients With Unresectable Hepatocellular Carcinoma

Journal of Clinical Oncology. doi: 10.1200/JCO.20.00808

 

ULBP1 Is Elevated in Human Hepatocellular Carcinoma and Predicts Outcome

Frontiers in Oncology. doi: 10.3389/fonc.2020.00971

 

Serum Alpha-fetoprotein Levels and Clinical Outcomes in the Phase III CELESTIAL Study of Cabozantinib versus Placebo in Patients with Advanced Hepatocellular Carcinoma

Clinical Cancer Research. doi: 10.1158/1078-0432.CCR-19-3884

 

Longevity and replenishment of human liver-resident memory T cells and mononuclear phagocytes

Journal of Experimental Medicine. doi: 10.1084/jem.20200050

 

Viral Hepatitides, Inflammation and Tumour Microenvironment

Advances in Experimental Medicine and Biology. doi: 10.1007/978-3-030-44518-8_3

 

Genetically driven CD39 expression shapes human tumor-infiltrating CD8+ T-cell functions

International Journal of Cancer. doi: 10.1002/ijc.33131

 

Homocysteinylated alpha 1 antitrypsin as an antigenic target of autoantibodies in seronegative rheumatoid arthritis patients

Journal of Autoimmunity. doi: 10.1016/j.jaut.2020.102470

 

Development of a Novel Inflammation-Based Index for Hepatocellular Carcinoma

Liver Cancer. doi: 10.1159/000504252

 

MTL-CEBPA, a Small Activating RNA Therapeutic Upregulating C/EBP-α, in Patients with Advanced Liver Cancer: A First-in-Human, Multicenter, Open-Label, Phase I Trial

Clinical Cancer Research. doi: 10.1158/1078-0432.CCR-20-0414

 

Energy metabolism and cell motility defect in NK-cells from patients with hepatocellular carcinoma

Cancer Immunology, Immunotherapy. doi: 10.1007/s00262-020-02561-4

 

Ramucirumab in elderly patients with hepatocellular carcinoma and elevated alpha-fetoprotein after sorafenib in REACH and REACH-2

Liver International. doi: 10.1111/liv.14462

 

Covariate-adjusted analysis of the Phase 3 REFLECT study of lenvatinib versus sorafenib in the treatment of unresectable hepatocellular carcinoma

British Journal of Cancer. doi: 10.1038/s41416-020-0817-7

 

Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications

Journal of Hepatology. doi: 10.1016/j.jhep.2020.03.025

 

Molecular classification and therapeutic targets in extrahepatic cholangiocarcinoma

Journal of Hepatology. doi: 10.1016/j.jhep.2020.03.008

 

Liver-resident CD8+ T cells: Learning lessons from the local experts

Journal of Hepatology. doi: 10.1016/j.jhep.2020.02.001

 

Combination of chemotherapy and PD-1 blockade induces T cell responses to tumor non-mutated neoantigens

Communications Biology. 2020 doi: 10.1038/s42003-020-0811-x

 

Effects of Subsequent Systemic Anticancer Medication Following First-Line Lenvatinib: A Post Hoc Responder Analysis from the Phase 3 REFLECT Study in Unresectable Hepatocellular Carcinoma

Liver Cancer. doi: 10.1159/000504624

 

Characterisation of the Serum Metabolic Signature of Cholangiocarcinoma in a United Kingdom Cohort

Journal of Clinical and Experimental Hepatology. doi: 10.1016/j.jceh.2019.06.001

 

Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors

Nature Communications. doi: 10.1038/s41467-020-14283-3

 

Human Liver Memory CD8+ T Cells Use Autophagy for Tissue Residence

Cell Reports. doi: 10.1016/j.celrep.2019.12.050

 

mRECIST for HCC: Performance and novel refinements

Journal of Hepatology. doi: 10.1016/j.jhep.2019.09.026

 

Milestones in the pathogenesis and management of primary liver cancer

Journal of Hepatology. doi: 10.1016/j.jhep.2019.11.006

 

Intratumoral heterogeneity and clonal evolution in liver cancer

Nature Communications. doi: 10.1038/s41467-019-14050-z

 

CNApp, a tool for the quantification of copy number alterations and integrative analysis revealing clinical implications

Elife. doi: 10.7554/eLife.50267

 

Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment

Aging Cell. doi: 10.1111/acel.13086

 

Applicability, safety, and biological activity of regulatory T cell therapy in liver transplantation

American Journal of Transplantation. doi: 10.1111/ajt.15700

 

Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy

The Journal of Clinical Investigations. doi: 10.1172/JCI127483

 

Liver transplant for hepatocellular carcinoma in the United States: Evolving trends over the last three decades

American Journal of Transplantation. doi: 10.1111/ajt.15576

 

Clinical Impact of Genomic Diversity From Early to Advanced Hepatocellular Carcinoma

Journal of Hepatology. doi: 10.1002/hep.30811