People
Matthew Hoare
Dr. Matt Hoare is Assistant Professor of Hepatology at the University of Cambridge, based at the CRUK Cambridge Institute and hepatologist at Addenbrooke’s Hospital in Cambridge. He currently leads the East of England service for hepatocellular carcinoma (HCC).
His research interests centre around the chronic liver disease and why patients with liver disease get cancer. He completed his PhD at Cambridge investigating the senescent or prematurely-aged immune cells in chronic viral hepatitis. Senescent cells have been identified in various liver diseases, where they have profound and sometimes contrasting effects upon their environment by transmitting inflammatory signals to their neighbours. During post-doctoral fellowships at the CRUK Cambridge Institute, he investigated mechanisms of senescence secretome control.
More recently he has defined the consequences of chronic liver disease upon DNA in the liver cells, allowing us to understand the burden of DNA damage in cirrhotic liver nodules. This work has developed an understanding of why patients with liver disease might develop cancer. These findings have the potential to be disruptive to our understanding of the pathogenesis of liver disease and potentially translate into novel drug targets.
You can view Matt's CRUK Cambridge Institute page here.