Publications

Herbert M, Surani A. Oocytes from stem cells. New England Journal of Medicine 2022, 386(2), 188-190.

Cavazza T, Takeda Y, Politi AZ, Aushev M, Aldag P, Baker C, Choudhary M, Bucevičius J, Lukinavičius G, Elder K, Blayney M, Lucas-Hahn A, Niemann H, Herbert M, Schuh M. Parental genome unification is highly error-prone in mammalian embryos. Cell 2021, 184(11), 2860-2877.e22. 

Mengoli V, Jonak K, Lyzak O, Lamb M, Lister LM, Lodge C, Rojas J, Zagoriy I, Herbert M, Zachariae W. Deprotection of centromeric cohesin at meiosis II requires APC/C activity but not kinetochore tension. EMBO Journal 2021, 40(7), e106812.

Aushev M, Herbert M. Mitochondrial genome editing gets precise. Nature 2020, 583(7817), 521-522. 

Yoshida S, Nishiyama S, Lister L, Hashimoto S, Mishina T, Courtois A, Kyogoku H, Abe T, Shiraishi A, Choudhary M, Nakaoka Y, Herbert M, Kitajima TS. Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes. Nature Communications 2020, 11(1), 2652.

Lodge C, Herbert M. Oocyte aneuploidy-more tools to tackle an old problem. PNAS 2020, 117(22), 11850-11852.

Reichmann J, Dobie K, Lister LM, Crichton JH, Best D, MacLennan M, Read D, Raymond ES, Hung CC, Boyle S, Shirahige K, Cooke HJ, Herbert M, Adams IR. Tex19.1 inhibits the N-end rule pathway and maintains acetylated SMC3 cohesin and sister chromatid cohesion in oocytes. Journal of Cell Biology 2020, 219(5), e201702123. 

Hudson G, Takeda Y, Herbert M. Reversion after replacement of mitochondrial DNA. Nature 2019, 574(7778), E8-E11.

Santibanez-Koref M, Griffin H, Turnbull DM, Chinnery PF, Herbert M, Hudson G. Assessing mitochondrial heteroplasmy using next generation sequencing: A note of caution. Mitochondrion 2019, 46, 302-306.

Carr-Wilkinson J, Prathalingam N, Pal D, Moad M, Lee N, Sundaresh A, Forgham H, James P, Herbert M, Lako M, Tweddle DA. Differentiation of Human Embryonic Stem Cells to Sympathetic Neurons: A Potential Model for Understanding Neuroblastoma Pathogenesis. Stem Cells International 2018, 2018, 4391641.

Otten ABC, Sallevelt SCEH, Carling PJ, Dreesen JCFM, Drüsedau M, Spierts S, Paulussen ADC, de Die-Smulders CEM, Herbert M, Chinnery PF, Samuels DC, Lindsey P, Smeets HJM. Mutation-specific effects in germline transmission of pathogenic mtDNA variants. Human Reproduction 2018, 33(7), 1331-1341.

Herbert M, Turnbull D. Progress in mitochondrial replacement therapies. Nature Reviews Molecular Cell Biology 2018, 19(2), 71–72.

Rattani A, Ballesteros Mejia R, Roberts K, Roig MB, Godwin J, Hopkins M, Eguren M, Sanchez-Pulido L, Okaz E, Ogushi S, Wolna M, Metson J, Pendas AM, Malumbres M, Novak B, Herbert M, Nasmyth K. APC/CCdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase ActivityCurrent Biology 2017, 27(10), 1462-1476.

Herbert M, Toth A. How Meiosis Creates the Single-Copy GenomeDevelopmental Cell 2017, 40(1), 3-4.

Herbert M, Turnbull D. Mitochondrial donation - Clearing the final regulatory hurdle in the United KingdomNew England Journal of Medicine 2017, 376(2), 171-173.

Craven L, Herbert M, Murdoch A, Murphy J, Davies JL, Turnbull DM. Research into Policy: A Brief History of Mitochondrial DonationStem Cells 2016, 34(2), 265-267.

Hyslop LA, Blakeley P, Craven L, Richardson J, Fogarty NME, Fragouli E, Lamb M, Wamaitha SE, Prathalingam N, Zhang Q, OKeefe H, Takeda Y, Arizzi L, Alfarawati S, Tuppen H, Irving L, Kalleas D, Choudhary M, Wells D, Murdoch AP, Turnbull DM, Niakan KK, Herbert M. Towards clinical application of pronuclear transfer to prevent mitochondrial DNA diseaseNature 2016, 534(7607), 383-386.

Richardson J, Irving L, Hyslop LA, Choudhary M, Murdoch A, Turnbull DM, Herbert M. Assisted Reproductive Technologies to Prevent Transmission of Mitochondrial DNA DiseaseStem Cells 2015, 33(3), 639-645.

Panagiotopoulou N, Ghuman N, Sandher R, Herbert M, Stewart JA. Barriers and facilitators towards fertility preservation care for cancer patients: A meta-synthesisEuropean Journal of Cancer Care 2015, e-pub ahead of print.

Pyle A, Hudson G, Wilson IJ, Coxhead J, Smertenko T, Herbert M, Santibanez-Koref M, Chinnery PF. Extreme-Depth Re-sequencing of Mitochondrial DNA Finds No Evidence of Paternal Transmission in HumansPLoS Genetics 2015, 11(5), e1005040.

Herbert M, Kalleas D, Cooney D, Lamb M, Lister L. Meiosis and Maternal Aging: Insights from Aneuploid Oocytes and Trisomy BirthsCold Spring Harbor Perspectives in Biology 2015, 7(4).

Gorman GS, Grady JP, Ng Y, Schaefer AM, McNally RJ, Chinnery PF, Man PY, Herbert M, Taylor RW, McFarland R, Turnbull DM. Mitochondrial Donation: How Many Women Could Benefit?New England Journal of Medicine 2015, 372(9), 885-887.

Herbert M, Turnbull D. Mitochondrial replacement to prevent the transmission of mitochondrial DNA diseaseEMBO Reports 2015, 16(5), 539-540.

Hyslop L, Irving L, Richardson J, Craven L, Choudhary M, Murdoch A, Turnbull D, Herbert M. Towards therapeutic application of IVF-based techniques to prevent transmission of mtDNA diseaseIn: 31st ESHRE Annual Meeting. 2015, Lisbon, Portugal: Oxford University Press.

Byerley SK, Blakely EW, Alston CL, Turnbull DM, Stewart JA, McFarland R, Taylor RW, Herbert M. PGD to prevent mitochondrial disease: embryological aspectsIn: 13th Annual Preimplantation Genetic Diagnosis International Society (PGDIS) Meeting. 2014, Canterbury, UK: Springer.

Craven L, Irving L, Alston CL, Watson EL, Byerley S, McFarland R, Stewart JA, Taylor RW, Herbert M, Turnbull DM. Preimplantation genetic diagnosis for mitochondrial DNA diseaseIn: 13th Annual Preimplantation Genetic Diagnosis International Society (PGDIS) Meeting. 2014, Canterbury, UK: Springer.

Sandher RK, Pickard R, Herbert M. Spermatogonial stem cells: a route to preserving fertiltiyIn: Society of Academic and Research Surgery Annual Meeting. 2014, Cambridge, UK: John Wiley & Sons, Inc.

Chinnery PF, Craven L, Mitalipov S, Stewart JB, Herbert M, Turnbull DM. The Challenges of Mitochondrial ReplacementPLoS Genetics 2014, 10(4), e1004315.

Greggains GD, Lister LM, Tuppen HAL, Zhang Q, Needham LH, Prathalingam N, Hyslop LA, Craven L, Polanski Z, Murdoch AP, Turnbull DM, Herbert M. Therapeutic potential of somatic cell nuclear transfer for degenerative disease caused by mitochondrial DNA mutationsScientific Reports 2014, 4, 3844.

Higgins JMG, Herbert M. Nucleosome Assembly Proteins Get SET to Defeat the Guardian of Chromosome CohesionPLoS Genetics 2013, 9, e1003829.

Hyslop L, Prathalingam N, Nowak L, Fenwick J, Harbottle S, Byerley S, Rhodes J, Watson B, Henderson R, Murdoch A, Herbert M. A Novel Isolator-Based System Promotes Viability of Human Embryos during Laboratory ProcessingPLoS ONE 2012, 7(2), e31010.

Craven L, Irving L, Herbert M, Turnbull D. Development of the Pronuclear Transfer Technique to Prevent Transmission of Mitochondrial DNA Disease in HumansIn: United Kingdom Neuromuscular Translational Research Conference. 2012, Newcastle upon Tyne: Elsevier.

Craven L, Irving L, Herbert M, Turnbull D. Development of the Pronuclear Transfer Technique to Prevent Transmission of Mitochondrial DNA Disease in HumansIn: UK Neuromuscular Translational Research Conference. 2012, Newcastle upon Tyne, UK: Elsevier.

Choudhary M, Nesbitt M, Burgess L, Hyslop L, Herbert M, Murdoch A. Egg Sharing for Research: A Successful Outcome for Patients and ResearchersCell Stem Cell 2012, 10(3), 239-240.

Prathalingam N, Ferguson L, Young L, Lietz G, Oldershaw R, Healy L, Craig A, Lister H, Binaykia R, Sheth R, Murdoch A, Herbert M. Production and validation of a good manufacturing practice grade human fibroblast line for supporting human embryonic stem cell derivation and cultureStem Cell Research and Therapy 2012, 3(2), 12.

Irving L, Alston C, Craven L, Herbert M, Turnbull DM. Analysis of mitochondrial DNA mutant loads in oocytes & preimplantation embryos for the 14709T > C & 14487T > C mtDNA mutations by pyrosequencingIn: United Kingdom Neuromuscular Translational Research Conference. 2011, London, UK: Elsevier.

Irving L, Craven L, Herbert M, Turnbull DM. Manipulation of human abnormally fertilized pronuclear stage zygotes following vitrificationIn: United Kingdom Neuromuscular Translational Research Conference. 2011, London, UK: Elsevier.

Craven L, Elson JL, Irving L, Tuppen HA, Lister LM, Greggains GD, Byerley S, Murdoch AP, Herbert M, Turnbull D. Mitochondrial DNA disease: new options for preventionHuman Molecular Genetics 2011, 20(R2), R168-R174.

Lister LM, Kouznetsova A, Hyslop LA, Kalleas D, Pace SL, Barel JC, Nathan A, Floros V, Adelfalk C, Watanabe Y, Jessberger R, Kirkwood TB, Hoog C, Herbert M. Age-Related Meiotic Segregation Errors in Mammalian Oocytes Are Preceded by Depletion of Cohesin and Sgo2Current Biology 2010, 20(17), 1511-1521.

Santos F, Hyslop L, Stojkovic P, Leary C, Murdoch A, Reik W, Stojkovic M, Herbert M, Dean W. Evaluation of epigenetic marks in human embryos derived from IVF and ICSIHuman Reproduction 2010, 25(9), 2387-2395.

Herbert M, Fenwick J, Harbottle S, Walker J. Laboratory Apparatus with Incubator. UK: NHS Innovations, 2010/0291664, 18/11/2010.

Craven L, Tuppen HA, Greggains GD, Harbottle SJ, Murphy JL, Cree LM, Murdoch AP, Chinnery PF, Taylor RW, Lightowlers RN, Herbert M, Turnbull DM. Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA diseaseNature 2010, 465(7294), 82-85.

Kouznetsova A, Lister L, Nordenskjold M, Herbert M, Hoog C. Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in miceNature Genetics 2007, 39(8), 966-968.

Brown D, Herbert M, Lamb V, Chinnery PF, Taylor R, Lightowlers R, Craven L, Cree L, Gardner JL, Turnbull DM. Transmission of mitochondrial DNA disorders: possibilities for the futureLancet 2006, 368(9529), 87-89.

Homer HA, McDougall A, Levasseur M, Murdoch AP, Herbert M. Mad2 is required for inhibiting securin and cyclin B degradation following spindle depolymerisation in meiosis I mouse oocytesReproduction 2005, 130(6), 829-843.

Homer HA, McDougall A, Levasseur M, Yallop K, Murdoch AP, Herbert M. Mad2 prevents aneuploidy and premature proteolysis of cyclin B and securin during meiosis I in mouse oocytesGenes and Development 2005, 19(2), 202-207.

Homer HA, McDougall A, Levasseur M, Herbert M. Restaging the spindle assembly checkpoint in female mammalian meiosis ICell Cycle 2005, 4(5), 650-653.

Herbert M, Levasseur M, Homer H, Yallop K, Murdoch A, McDougall A. Homologue disjunction in mouse oocytes requires proteolysis of securin and cyclin B1Nature Cell Biology 2003, 5(11), 1023-1025.

Fenwick J, Platteau P, Murdoch AP, Herbert M. Time from insemination to first cleavage predicts developmental competence of human preimplantation embryos in vitroHuman Reproduction 2002, 17(2), 407-412.

Griffiths TA, Murdoch AP, Herbert M. Embryonic development in vitro is compromised by the ICSI procedureHuman Reproduction 2000, 15(7), 1592-1596.

Herbert M, Morgan J, Levasseur M, Murdoch AP, McDougall A. A non-degradable form of cyclin can be used to induce arrest at the first meiotic metaphase in human oocytesIn: ESHRE campus workshop 'ART in the year 2000'. 1999, Hamburg-Norderstedt, Germany: Oxford University Press.

Evbuomwan IO, Fenwick JD, Shiels R, Herbert M, Murdoch AP. Severe ovarian hyperstimulation syndrome following salvage of empty follicle syndromeHuman Reproduction 1999, 14(7), 1707-1709.

Clouston,H.J., Fenwick,J., Webb,A.L., Herbert,M. Murdoch,A.P., Wolstenholme,J. Detection of mosaic and non-mosaic chromosome abnormalities in 6-8 day old human blastocystsHuman Genetics 1997, 101, 30-36.