About the Trial

LB and PDD are complex illnesses with a wide range of symptoms, which vary from person to person. Cholinesterase Inhibitors (such as donepezil, rivastigmine and galantamine) can help people with DLB/PDD by improving day to day functioning and thinking abilities.

Another drug which might help is Memantine. Memantine is a prescription drug used together with Cholinesterase Inhibitors to treat moderate to severe confusion in Alzheimer’s disease and may help to improve memory, awareness and the ability to perform daily functions. At the moment it is not clear if taking Memantine at the same time as a cholinesterase inhibitor will help people with DLB/PDD.

COBALT aims to find out if adding Memantine to a cholinesterase improves overall health and functioning for people with DLB or PDD.