About our Project


 The project has several aims:

  • To determine the repetoire of proteins that both interact and are ubiquitinated by the E3 ligase WWP2
  • To determine how the loss of WWP2 affects cartilage formation
  • To understand whether there is an interconnection between WWP2 and the microRNA, miR-140, located within an intron of the gene.
  • To characterise the phenotype of a mouse lacking the cartilage specific isoforma of Wwp2

Wwp2 cartilage isoform deletion

UCSC browser view of the confirmation of the deletion of the Wwp2 cartilage-specific isoform, generated as part of this project

String analysis of WWP2

Known interactions of WWP2, as identified using String