The primary objective of the study is to measure the immune dysregulation immediately prior to RA flare

In order to investigate this we will focus on:

• Circulating immune cell subsets, their activation status and cytokine profiles
• Autoantibody profiles and other circulating mediators
• Synovial cellular subpopulations
• Metabolic profiles related to immune and/or synovial activation
• Epigenetic profiles

The secondary objectives of the study are:

• To corroborate baseline biomarkers predictive of sustained DMARD-free remission, as identified by the Biomarkers of Remission in Rheumatoid Arthritis (BioRRA) study
• To collect biological samples for future discovery research
• To establish the utility of physical activity monitoring (via accelerometry) to assist in the early detection of flare