2018 participants
Phumrapee Boonklang
Transplantation is the most effective therapy for treating organ failure. Despite its success it is limited by the number of donor organs available relative to the number of patients on the waiting list. The ever increasing number of patients on transplant waiting lists has put a greater emphasis on the preservation of organ function and increased use of donor organs which would previously have been considered too compromised for clinical use. Hence, there is urgent need to evaluate novel approaches that increase the availability of suitable donor organs and overcome early inflammation. In this project using a pre-optimised cell culture system we will examine the potential of Lipid molecule (S1P) and related drugs to maintain the integrity of blood vessels. This study may identify drugs which can be used in perfusion of organs before transplantation to restore the integrity of blood vessels and therefore limit the risk of early injury.
Funding source: Wellcome Trust
Supervisor: Professor Simi Ali