Eloise James

• MBBS
• Genome dynamics and phylogenetic tracking in paired diagnostic and relapsed neuroblastomas

My project, at the Northern Institute for Cancer Research, focused on neuroblastoma, a rare childhood cancer with a high mortality rate. High risk groups show 50% survival, and therefore research into genetics and treatment is pertinent. I extracted genetic material from 9 tumours at diagnosis and relapse, and analysed corresponding existing genetic data.

The aim was to determine genetic changes occurring from diagnosis to relapse, to identify areas for research and inform risk stratification/treatment. Samples in the lab were extracted, and genetic analysis software/pipelines were used. I attended my supervisor’s hospital neuroblastoma clinic, where I met patients that had donated their tumours, which was invaluable.

In reading literature regarding the disease and proposed pathophysiology of relapse, and comparing this each tumour’s genetic data, I was able to discuss and conclude my findings. I identified routes for further genetic exploration that may indicate atypical relapse, and this may hopefully inform future treatment.  

Funding source: Newcastle University

Supervisor: Professor Deborah A. Tweddle & Dr Alem Gabriel