The EDETOX database was developed during the EDETOX project by Sarah Soyei and Faith Williams at Newcastle University.
The Database contains data that has been produced by in vitro and in vivo percutaneous penetration studies. These have been compiled from the published literature. The information can be used to establish and validate mathematical models that have been produced to predict percutaneous penetration. The data can be filtered in a variety of ways and can be extracted in printed reports or exported to excel spreadsheets.
The EDETOX database has been widely used as a basis for extended databases, QSAR and modelling eg:
www.ilsi.org/Europe/Pages/COSMOS.aspx( 2014). Development of dermal absorption database for cosmetic chemicals from existing databases and peer reviewed literature.
Samaras, EG, Rivieire,JE and Ghafourian T (2012) The effect of formulations and experimental conditions on in vitro human skin permeation- Data from updated EDETOX database. International Journal of Pharmaceutics 434, 280-291
Guy RH (2010) Predicting the rate and extent of fragrance chemical absorption into and through the skin. Chem Res Toxicol 23 864-870
Bouwman, T, Cronin, MT, Bessems,JG and van der Sandt JJ ( 2008) Improving the applicability of (Q)SARs for percutaneous penetration in regulatory risk assessment. Hum Exp Toxicol.27 269-276
Faith M Williams, Helga Reithe, Gordon Barratt, Alexandro Chiodini, Jacqueline Whyte, Mark T D Cronin, Nancy A Monteiro- Riviere, James Plautz, Clive Roper, Jooost Westerhout, Chihae Yang, Richard H Guy. (2016) Assessing the safety of cosmetic chemicals:consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral TTC (Threshold of Toxicological Concern) Reg Toxicol Pharmacol 76, 174-186
All available studies on a particular chemical have been entered on to the database and an assessment has been made as to whether information fits EDETOX criteria. In order for a study to satisfy EDETOX criteria the following must all be clearly stated:
If the reasons why a study does not meet EDETOX Criteria are not clear, an explanation is found in the notes section of the record.