Acknowledgements

 The Newcastle 85+ Study has been funded by: 

Parts of the work have also been funded by: 

 We acknowledge the operational support of NHS North of Tyne and of the local general practitioners and their staff.

 We thank the research nurses, laboratory technicians, data management and clerical team for outstanding work throughout, as well as many colleagues for their expert advice.

 Thanks are due especially to the study participants and, where appropriate, their families and carers.