NCTU
Newcastle Neurosurgery Clinical Trials Unit

Neurosurgical Clinical Trial Unit
Neurosurgical Clinical Trial Unit - ACST 2

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ACST II

ACST

International randomised trial to determine whether surgery (CEA) in patients with asymptomatic disease reduces the risk of stroke when compared to stenting.

ACST II is a randomised trial comparing carotid endarterectomy (CEA) and carotid stenting as treatment for asymptomatic carotid stenosis. The trial will compare the immediate hazards or the two procedures using both short and long-term follow up over the next 5-10 years.


Brief inclusion / exclusion criteria

Inclusion:

  • Carotid artery stenosis, confirmed by duplex ultrasound, which is technically and clinically appropriate for operation or stenting
  • No ipsilateral carotid territory symptoms for at least 6 months
  • Doctor and patient substantially uncertain about whether to treat with CEA or CAS
  • Patient fit and willing for to participate in at least 5 years follow-up

    • Exclusion:

  • Previous CEA or CAS in randomised artery
  • Small likelihood of worthwhile benefit (e.g. very low risk of stroke, or presence of other major life-threatening disease)
  • High risk of adverse events of trial treatment (e.g. inaccessible stenosis)
  • Considered to be unsuitable for either CEA or CAS
  • Patient unable or unwilling to give informed consent
    		•
    Staff Involved

    Principal Investigators:

    Miss. A. Halliday (London)
    Dr. D. Thomas (London)
    Prof. A. Mansfield (London)

    Prof. A.D. Mendelow

    		 Assigned Registrar: Mr. C. Barrett

    IMASH


    Last updated 29 Jan 2007
    © NCTU Email: NCTU@ncl.ac.uk